Identifying blood-brain-barrier selective single-chain antibody fragments

The blood–brain barrier (BBB) represents an obstacle in targeting and delivering therapeutics to the central nervous system. In order to discover new BBB‐targeting molecules, we panned a phage‐displayed nonimmune human single‐chain antibody fragment (scFv) library against a representative BBB model...

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Veröffentlicht in:	Biotechnology journal 2014-05, Vol.9 (5), p.664-674
Hauptverfasser:	Jones, Angela R., Stutz, C. Christopher, Zhou, Yu, Marks, James D., Shusta, Eric V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Blood-brain barrier Blood-Brain Barrier - chemistry Blood-Brain Barrier - metabolism Brain - cytology Brain targeting Cell Surface Display Techniques Cells, Cultured Combinatorial screening Endothelial Cells - cytology Histocytochemistry Male Phage display Rats Rats, Sprague-Dawley Single-Chain Antibodies - chemistry Single-Chain Antibodies - genetics Single-Chain Antibodies - metabolism Tissue Distribution
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