Potent Cytotoxic Arylnaphthalene Lignan Lactones from Phyllanthus poilanei

Two new (1 and 2) and four known arylnaphthalene lignan lactones (3–6) were isolated from different plant parts of Phyllanthus poilanei collected in Vietnam, with two further known analogues (7 and 8) being prepared from phyllanthusmin C (4). The structures of the new compounds were determined by in...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-06, Vol.77 (6), p.1494-1504
Hauptverfasser:	Ren, Yulin, Lantvit, Daniel D, Deng, Youcai, Kanagasabai, Ragu, Gallucci, Judith C, Ninh, Tran Ngoc, Chai, Hee-Byung, Soejarto, Djaja D, Fuchs, James R, Yalowich, Jack C, Yu, Jianhua, Swanson, Steven M, Kinghorn, A. Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology apoptosis Benzodioxoles - chemistry Caspase 3 - drug effects caspase-3 colorectal neoplasms cytotoxicity DNA topoisomerase DNA Topoisomerases, Type I - drug effects DNA Topoisomerases, Type I - metabolism Drug Screening Assays, Antitumor Glycosides - chemistry HT29 Cells Humans inhibitory concentration 50 lactones Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology lignans Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Mice Molecular Structure Naphthalenes - chemistry Naphthalenes - isolation & purification Naphthalenes - pharmacology neoplasm cells Nuclear Magnetic Resonance, Biomolecular Phyllanthus Phyllanthus - chemistry plant anatomy spectral analysis Vietnam X-ray diffraction
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