Organ specific mapping of in vivo redox state in control and cigarette smoke-exposed mice using EPR/NMR co-imaging

[Display omitted] ► EPR/NMR co-imaging detected the distribution of a nitroxide probe in living mice. ► 3D mapping of the in vivo distribution and metabolism of the probe was performed. ► Organ specific differences of in probe uptake, metabolism and clearance were imaged. ► Reductive metabolism was...

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Veröffentlicht in:	Journal of magnetic resonance (1997) 2012-03, Vol.216, p.21-27
Hauptverfasser:	Caia, George L., Efimova, Olga V., Velayutham, Murugesan, El-Mahdy, Mohamed A., Abdelghany, Tamer M., Kesselring, Eric, Petryakov, Sergey, Sun, Ziqi, Samouilov, Alexandre, Zweier, Jay L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atmosphere Exposure Chambers Biocompatibility Biomedical materials Cigarette smoking Cyclic N-Oxides Electromagnetic Fields Electron Spin Resonance Spectroscopy EPR/NMR co-imaging EPRI Free radicals Image Processing, Computer-Assisted In vivo redox state In vivo testing Magnetic Resonance Imaging Male Mapping Mice Mice, Inbred C57BL Nicotiana - chemistry Nitrogen Oxides - chemistry Nitroxide Nuclear magnetic resonance Organ Specificity Organs Oxidation-Reduction Oxidative Stress Proton MRI Pyrrolidines Smoke - adverse effects Spin Labels Surgical implants Tissue Distribution
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