Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus

Voltage-dependent block of the NMDA receptor by Mg2+ is thought to be central to the unique involvement of this receptor in higher brain functions. However, the in vivo role of the Mg2+ block in the mammalian brain has not yet been investigated, because brain-wide loss of the Mg2+ block causes perin...

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Veröffentlicht in:	Molecular brain 2014-06, Vol.7 (1), p.44-44
Hauptverfasser:	Hayashi, Yuichiro, Nabeshima, Yoko, Kobayashi, Katsunori, Miyakawa, Tsuyoshi, Tanda, Koichi, Takao, Keizo, Suzuki, Hidenori, Esumi, Eisaku, Noguchi, Shigeru, Matsuda, Yukiko, Sasaoka, Toshikuni, Noda, Tetsuo, Miyazaki, Jun-ichi, Mishina, Masayoshi, Funabiki, Kazuo, Nabeshima, Yo-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Amino acids Animals Base Sequence Behavior Biomedical research Dentate Gyrus - drug effects Dentate Gyrus - metabolism Dentate Gyrus - pathology Dentate Gyrus - physiopathology Excitatory Postsynaptic Potentials - drug effects Experiments Gene Targeting Integrases - metabolism Laboratories Magnesium Magnesium - pharmacology Medical research Medicine Mice Mice, Neurologic Mutants Molecular Sequence Data Mutant Proteins - metabolism Mutation Neurogenesis - drug effects Neuronal Plasticity - drug effects Neurosciences Organ Specificity - drug effects Physiological aspects Protein Subunits - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Rodents Science Semiconductor industry Software University graduates
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