Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology
Mate preference behavior is an essential first step in sexual selection and is a critical determinant in evolutionary biology. Previously an environmental compound (the fungicide vinclozolin) was found to promote the epigenetic transgenerational inheritance of an altered sperm epigenome and modified...
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| Veröffentlicht in: | BMC genomics 2014-05, Vol.15 (1), p.377-377 |
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| creator | Skinner, Michael K Savenkova, Marina I Zhang, Bin Gore, Andrea C Crews, David |
| description | Mate preference behavior is an essential first step in sexual selection and is a critical determinant in evolutionary biology. Previously an environmental compound (the fungicide vinclozolin) was found to promote the epigenetic transgenerational inheritance of an altered sperm epigenome and modified mate preference characteristics for three generations after exposure of a gestating female.
The current study investigated gene networks involved in various regions of the brain that correlated with the altered mate preference behavior in the male and female. Statistically significant correlations of gene clusters and modules were identified to associate with specific mate preference behaviors. This novel systems biology approach identified gene networks (bionetworks) involved in sex-specific mate preference behavior. Observations demonstrate the ability of environmental factors to promote the epigenetic transgenerational inheritance of this altered evolutionary biology determinant.
Combined observations elucidate the potential molecular control of mate preference behavior and suggests environmental epigenetics can have a role in evolutionary biology. |
| doi_str_mv | 10.1186/1471-2164-15-377 |
| format | Article |
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The current study investigated gene networks involved in various regions of the brain that correlated with the altered mate preference behavior in the male and female. Statistically significant correlations of gene clusters and modules were identified to associate with specific mate preference behaviors. This novel systems biology approach identified gene networks (bionetworks) involved in sex-specific mate preference behavior. Observations demonstrate the ability of environmental factors to promote the epigenetic transgenerational inheritance of this altered evolutionary biology determinant.
Combined observations elucidate the potential molecular control of mate preference behavior and suggests environmental epigenetics can have a role in evolutionary biology.</description><identifier>ISSN: 1471-2164</identifier><identifier>EISSN: 1471-2164</identifier><identifier>DOI: 10.1186/1471-2164-15-377</identifier><identifier>PMID: 24885959</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Biological Evolution ; Brain - metabolism ; Cluster Analysis ; DNA methylation ; Environment ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Gene-Environment Interaction ; Genetic aspects ; Genetic research ; Genomics ; Humans ; Male ; Mutation ; Quantitative Trait, Heritable ; Rats ; Rodents ; Sexual Behavior, Animal ; Signal Transduction</subject><ispartof>BMC genomics, 2014-05, Vol.15 (1), p.377-377</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Skinner et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Skinner et al.; licensee BioMed Central Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b5337-e2fd39dc8cd631fa7ab422cae0d5f30412cac90b453eb960b838a8e0fc900fda3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073506/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073506/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24885959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skinner, Michael K</creatorcontrib><creatorcontrib>Savenkova, Marina I</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Gore, Andrea C</creatorcontrib><creatorcontrib>Crews, David</creatorcontrib><title>Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology</title><title>BMC genomics</title><addtitle>BMC Genomics</addtitle><description>Mate preference behavior is an essential first step in sexual selection and is a critical determinant in evolutionary biology. Previously an environmental compound (the fungicide vinclozolin) was found to promote the epigenetic transgenerational inheritance of an altered sperm epigenome and modified mate preference characteristics for three generations after exposure of a gestating female.
The current study investigated gene networks involved in various regions of the brain that correlated with the altered mate preference behavior in the male and female. Statistically significant correlations of gene clusters and modules were identified to associate with specific mate preference behaviors. This novel systems biology approach identified gene networks (bionetworks) involved in sex-specific mate preference behavior. Observations demonstrate the ability of environmental factors to promote the epigenetic transgenerational inheritance of this altered evolutionary biology determinant.
Combined observations elucidate the potential molecular control of mate preference behavior and suggests environmental epigenetics can have a role in evolutionary biology.</description><subject>Animals</subject><subject>Biological Evolution</subject><subject>Brain - metabolism</subject><subject>Cluster Analysis</subject><subject>DNA methylation</subject><subject>Environment</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Gene Regulatory Networks</subject><subject>Gene-Environment Interaction</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Genomics</subject><subject>Humans</subject><subject>Male</subject><subject>Mutation</subject><subject>Quantitative Trait, Heritable</subject><subject>Rats</subject><subject>Rodents</subject><subject>Sexual Behavior, Animal</subject><subject>Signal Transduction</subject><issn>1471-2164</issn><issn>1471-2164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk1v1DAQhiMEoqVw54QscYFDih3b-eBQqVpBqVQJiY-z5TiTrUtiL7az0H_Cz2WyW7ZdVIRy8HjmmdeTmcmy54weM1aXb5ioWF6wUuRM5ryqHmSHO9fDO_ZB9iTGK0pZVRfycXZQiLqWjWwOs19n4IC01jtIP3z4Fol1az-soUODpEsgsLJLZJI1JAXt4nwJOmGGHpC5hGCTdgaI74keEgRMHXUCsgrQ4w1Dbwm4tQ3ejeASZt1KRqJdRwBfnDaK4XquZfDL66fZo14PEZ7dnEfZ1_fvviw-5Bcfz84Xpxd5Kzmvcij6jjedqU1XctbrSreiKIwG2smeU8HQNg1theTQNiVta17rGmiPTtp3mh9lJ1vd1dSO0BmsMOhBrYIdsRrltVX7EWcv1dKvlaAVl7REgcVWAAv_h8B-xPhRzZNR82QUkwoHhyqvbsoI_vsEManRRgPDoB34KSImBI5PbB78L8p4hV0QiL78C73yU8DBbSj8gYoW_JZa6gGUdb3HOs0sqk4lb2Qpa86QOr6Hwq-D0Rrcn96ify_h9V4CMgl-pqWeYlTnnz_ts3TLmuBjxMXZ9Y9RNa_6fR17cXdwu4Q_u81_A-S9_K8</recordid><startdate>20140516</startdate><enddate>20140516</enddate><creator>Skinner, Michael K</creator><creator>Savenkova, Marina I</creator><creator>Zhang, Bin</creator><creator>Gore, Andrea C</creator><creator>Crews, David</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope><scope>5PM</scope></search><sort><creationdate>20140516</creationdate><title>Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology</title><author>Skinner, Michael K ; Savenkova, Marina I ; Zhang, Bin ; Gore, Andrea C ; Crews, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b5337-e2fd39dc8cd631fa7ab422cae0d5f30412cac90b453eb960b838a8e0fc900fda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biological Evolution</topic><topic>Brain - metabolism</topic><topic>Cluster Analysis</topic><topic>DNA methylation</topic><topic>Environment</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetic inheritance</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation</topic><topic>Gene Regulatory Networks</topic><topic>Gene-Environment Interaction</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>Genomics</topic><topic>Humans</topic><topic>Male</topic><topic>Mutation</topic><topic>Quantitative Trait, Heritable</topic><topic>Rats</topic><topic>Rodents</topic><topic>Sexual Behavior, Animal</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skinner, Michael K</creatorcontrib><creatorcontrib>Savenkova, Marina I</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Gore, Andrea C</creatorcontrib><creatorcontrib>Crews, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skinner, Michael K</au><au>Savenkova, Marina I</au><au>Zhang, Bin</au><au>Gore, Andrea C</au><au>Crews, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology</atitle><jtitle>BMC genomics</jtitle><addtitle>BMC Genomics</addtitle><date>2014-05-16</date><risdate>2014</risdate><volume>15</volume><issue>1</issue><spage>377</spage><epage>377</epage><pages>377-377</pages><issn>1471-2164</issn><eissn>1471-2164</eissn><abstract>Mate preference behavior is an essential first step in sexual selection and is a critical determinant in evolutionary biology. Previously an environmental compound (the fungicide vinclozolin) was found to promote the epigenetic transgenerational inheritance of an altered sperm epigenome and modified mate preference characteristics for three generations after exposure of a gestating female.
The current study investigated gene networks involved in various regions of the brain that correlated with the altered mate preference behavior in the male and female. Statistically significant correlations of gene clusters and modules were identified to associate with specific mate preference behaviors. This novel systems biology approach identified gene networks (bionetworks) involved in sex-specific mate preference behavior. Observations demonstrate the ability of environmental factors to promote the epigenetic transgenerational inheritance of this altered evolutionary biology determinant.
Combined observations elucidate the potential molecular control of mate preference behavior and suggests environmental epigenetics can have a role in evolutionary biology.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24885959</pmid><doi>10.1186/1471-2164-15-377</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological Evolution Brain - metabolism Cluster Analysis DNA methylation Environment Epigenesis, Genetic Epigenetic inheritance Epigenetics Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Gene-Environment Interaction Genetic aspects Genetic research Genomics Humans Male Mutation Quantitative Trait, Heritable Rats Rodents Sexual Behavior, Animal Signal Transduction |
| title | Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology |
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