Contribution of genetic variation to transgenerational inheritance of DNA methylation

Despite the important role DNA methylation plays in transcriptional regulation, the transgenerational inheritance of DNA methylation is not well understood. The genetic heritability of DNA methylation has been estimated using twin pairs, although concern has been expressed whether the underlying ass...

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Veröffentlicht in:	Genome Biology (Online Edition) 2014-05, Vol.15 (5), p.R73-R73, Article R73
Hauptverfasser:	McRae, Allan F, Powell, Joseph E, Henders, Anjali K, Bowdler, Lisa, Hemani, Gibran, Shah, Sonia, Painter, Jodie N, Martin, Nicholas G, Visscher, Peter M, Montgomery, Grant W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Chromosomes, Human DNA Methylation DNA sequencing European Continental Ancestry Group - genetics Genes Genetic aspects Genetic transcription Genetic Variation Humans Molecular Sequence Data Nucleotide sequencing Oligonucleotide Array Sequence Analysis - methods Pedigree Polymorphism, Single Nucleotide Twins, Dizygotic - genetics Twins, Monozygotic - genetics
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