Medial vascular calcification revisited: review and perspectives
Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes...
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| Veröffentlicht in: | European heart journal 2014-06, Vol.35 (23), p.1515-1525 |
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| container_issue | 23 |
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| container_title | European heart journal |
| container_volume | 35 |
| creator | Lanzer, Peter Boehm, Manfred Sorribas, Victor Thiriet, Marc Janzen, Jan Zeller, Thomas St Hilaire, Cynthia Shanahan, Catherine |
| description | Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area. |
| doi_str_mv | 10.1093/eurheartj/ehu163 |
| format | Article |
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Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehu163</identifier><identifier>PMID: 24740885</identifier><language>eng</language><publisher>England: Oxford University Press (OUP)</publisher><subject>Adult ; Arteriosclerosis - pathology ; Arteriosclerosis - physiopathology ; Biomarkers - metabolism ; Calcium-Binding Proteins - physiology ; Cardiology and cardiovascular system ; Diabetes Mellitus, Type 2 - pathology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Angiopathies - pathology ; Diabetic Angiopathies - physiopathology ; Female ; Human health and pathology ; Humans ; Hyperphosphatemia - physiopathology ; Life Sciences ; Male ; Monckeberg Medial Calcific Sclerosis - pathology ; Monckeberg Medial Calcific Sclerosis - physiopathology ; Monckeberg Medial Calcific Sclerosis - therapy ; Phosphates - physiology ; Prognosis ; Renal Insufficiency, Chronic - physiopathology ; Reviews ; Terminology as Topic ; Tunica Intima - pathology ; Tunica Intima - physiopathology ; Tunica Media - pathology ; Tunica Media - physiopathology ; Vascular Calcification - pathology ; Vascular Calcification - physiopathology ; Vascular Calcification - therapy</subject><ispartof>European heart journal, 2014-06, Vol.35 (23), p.1515-1525</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.</rights><rights>Attribution - NonCommercial</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. 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Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.</description><subject>Adult</subject><subject>Arteriosclerosis - pathology</subject><subject>Arteriosclerosis - physiopathology</subject><subject>Biomarkers - metabolism</subject><subject>Calcium-Binding Proteins - physiology</subject><subject>Cardiology and cardiovascular system</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Angiopathies - pathology</subject><subject>Diabetic Angiopathies - physiopathology</subject><subject>Female</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hyperphosphatemia - physiopathology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Monckeberg Medial Calcific Sclerosis - pathology</subject><subject>Monckeberg Medial Calcific Sclerosis - physiopathology</subject><subject>Monckeberg Medial Calcific Sclerosis - therapy</subject><subject>Phosphates - physiology</subject><subject>Prognosis</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Reviews</subject><subject>Terminology as Topic</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Intima - physiopathology</subject><subject>Tunica Media - pathology</subject><subject>Tunica Media - physiopathology</subject><subject>Vascular Calcification - pathology</subject><subject>Vascular Calcification - physiopathology</subject><subject>Vascular Calcification - therapy</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1PwzAMhiMEYuPjzgn1yqHMaZo25YCYJmBIQ1xA4halqUMzdd2UtEX8ezoKE3CyZft5ZT2EnFG4pJCxCbauROWa5QTLliZsj4wpj6IwS2K-T8ZAMx4miXgdkSPvlwAgEpocklEUpzEIwcfk5hELq6qgU163lXKBVpW2xmrV2HUdOOystw0WV18tvgeqLoINOr9B3dgO_Qk5MKryePpdj8nL3e3zbB4unu4fZtNFqGMGTYgpMIE0h5RrCilVhrOcU8NFphlClJscMeFZpnMKKjIF08YwVFlMTSJ4wY7J9ZC7afMVFhrrxqlKbpxdKfch18rKv5valvJt3ckY0khkrA-4GALKf9h8upDbGVAm4t5cR_tbGG61W3vv0OwACnJrXu7My8F8j5z__m8H_Khmn8mHhN0</recordid><startdate>20140614</startdate><enddate>20140614</enddate><creator>Lanzer, Peter</creator><creator>Boehm, Manfred</creator><creator>Sorribas, Victor</creator><creator>Thiriet, Marc</creator><creator>Janzen, Jan</creator><creator>Zeller, Thomas</creator><creator>St Hilaire, Cynthia</creator><creator>Shanahan, Catherine</creator><general>Oxford University Press (OUP)</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope></search><sort><creationdate>20140614</creationdate><title>Medial vascular calcification revisited: review and perspectives</title><author>Lanzer, Peter ; 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Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.</abstract><cop>England</cop><pub>Oxford University Press (OUP)</pub><pmid>24740885</pmid><doi>10.1093/eurheartj/ehu163</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Arteriosclerosis - pathology Arteriosclerosis - physiopathology Biomarkers - metabolism Calcium-Binding Proteins - physiology Cardiology and cardiovascular system Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - pathology Diabetic Angiopathies - physiopathology Female Human health and pathology Humans Hyperphosphatemia - physiopathology Life Sciences Male Monckeberg Medial Calcific Sclerosis - pathology Monckeberg Medial Calcific Sclerosis - physiopathology Monckeberg Medial Calcific Sclerosis - therapy Phosphates - physiology Prognosis Renal Insufficiency, Chronic - physiopathology Reviews Terminology as Topic Tunica Intima - pathology Tunica Intima - physiopathology Tunica Media - pathology Tunica Media - physiopathology Vascular Calcification - pathology Vascular Calcification - physiopathology Vascular Calcification - therapy |
| title | Medial vascular calcification revisited: review and perspectives |
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