Medial vascular calcification revisited: review and perspectives

Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes...

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Veröffentlicht in:European heart journal 2014-06, Vol.35 (23), p.1515-1525
Hauptverfasser: Lanzer, Peter, Boehm, Manfred, Sorribas, Victor, Thiriet, Marc, Janzen, Jan, Zeller, Thomas, St Hilaire, Cynthia, Shanahan, Catherine
Format: Artikel
Sprache:eng
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Zusammenfassung:Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehu163