Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity
Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes. In a previous study, the ethanol extract of berries of V. vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulat...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-10 |
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| creator | Haddad, Pierre S. Musallam, Lina Vallerand, Diane Brault, Antoine Ouchfoun, Meriem Eid, Hoda M. Arnason, John |
| description | Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes. In a previous study, the ethanol extract of berries of V. vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK) pathway. The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes. C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids) for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO) were used. Treatment began by adding V. vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg) for a subsequent period of 8 weeks (total HFD, 16 weeks). The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model. This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle. V. vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways. The results of the present study confirm that V. vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies. |
| doi_str_mv | 10.1155/2014/645812 |
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Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity</title><source>Wiley Online Library Open Access</source><source>Free E-Journal (出版社公開部分のみ）</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Haddad, Pierre S. ; Musallam, Lina ; Vallerand, Diane ; Brault, Antoine ; Ouchfoun, Meriem ; Eid, Hoda M. ; Arnason, John</creator><contributor>Nammi, Srinivas ; Srinivas Nammi</contributor><creatorcontrib>Haddad, Pierre S. ; Musallam, Lina ; Vallerand, Diane ; Brault, Antoine ; Ouchfoun, Meriem ; Eid, Hoda M. ; Arnason, John ; Nammi, Srinivas ; Srinivas Nammi</creatorcontrib><description>Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes. In a previous study, the ethanol extract of berries of V. vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK) pathway. The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes. C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids) for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO) were used. Treatment began by adding V. vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg) for a subsequent period of 8 weeks (total HFD, 16 weeks). The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model. This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle. V. vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways. The results of the present study confirm that V. vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2014/645812</identifier><identifier>PMID: 25013446</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>AKT protein ; AMP ; AMP-activated protein kinase ; Antidiabetics ; Berries ; Blood glucose ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Ethanol ; Fatty liver ; Fruits ; Glucose ; High fat diet ; Insulin ; Insulin resistance ; Kinases ; Lipids ; Liver ; Muscles ; Obesity ; Plant extracts ; Rodents ; Skeletal muscle ; Steatosis ; Vaccinium vitis-idaea</subject><ispartof>Evidence-based complementary and alternative medicine, 2014-01, Vol.2014 (2014), p.1-10</ispartof><rights>Copyright © 2014 Hoda M. Eid et al.</rights><rights>Copyright © 2014 Hoda M. Eid et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2014 Hoda M. Eid et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-b87c270b206287dfaea3677b0157829541ab5558ebee5e204c0a38f6ed5d98a73</citedby><cites>FETCH-LOGICAL-c467t-b87c270b206287dfaea3677b0157829541ab5558ebee5e204c0a38f6ed5d98a73</cites><orcidid>0000-0002-8991-3011</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072050/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072050/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25013446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nammi, Srinivas</contributor><contributor>Srinivas Nammi</contributor><creatorcontrib>Haddad, Pierre S.</creatorcontrib><creatorcontrib>Musallam, Lina</creatorcontrib><creatorcontrib>Vallerand, Diane</creatorcontrib><creatorcontrib>Brault, Antoine</creatorcontrib><creatorcontrib>Ouchfoun, Meriem</creatorcontrib><creatorcontrib>Eid, Hoda M.</creatorcontrib><creatorcontrib>Arnason, John</creatorcontrib><title>Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes. In a previous study, the ethanol extract of berries of V. vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK) pathway. The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes. C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids) for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO) were used. Treatment began by adding V. vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg) for a subsequent period of 8 weeks (total HFD, 16 weeks). The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model. This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle. V. vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways. The results of the present study confirm that V. vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies.</description><subject>AKT protein</subject><subject>AMP</subject><subject>AMP-activated protein kinase</subject><subject>Antidiabetics</subject><subject>Berries</subject><subject>Blood glucose</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Ethanol</subject><subject>Fatty liver</subject><subject>Fruits</subject><subject>Glucose</subject><subject>High fat diet</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Liver</subject><subject>Muscles</subject><subject>Obesity</subject><subject>Plant extracts</subject><subject>Rodents</subject><subject>Skeletal muscle</subject><subject>Steatosis</subject><subject>Vaccinium vitis-idaea</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0c1rFDEYBvBBFFurJ-8S8FKVafM5yV6Epa1aWOlFxVvIxzvdt8xmtpOZ2v3vzbJ1qZ68JIH8eHlenqp6zegJY0qdcsrkaSOVYfxJdci0ZLXkxjzdv_XPg-pFzjeU8pnW-nl1wBVlQsrmsFovMF33ycMwbMjxDxcCJpxW5A5HzDVGB44sTt6Ri_slehwzmacRIzoPIwYyDyNuJWSCiTjytZ8ylDNCR_qWnCOM9WWKU4BIrjxkHDcvq2et6zK8eriPqu-fLr6dfakXV58vz-aLOshGj7U3OnBNPacNNzq2JYdotPaUKW34TEnmvFLKgAdQwKkM1AnTNhBVnBmnxVH1cTd3PfkVxABpHFxn1wOu3LCxvUP790_Cpb3u76ykmlNFy4DjhwFDfztBHu0Kc4CucwnKmpYpKbVohNzSt__Qm34aUlnPlvzUMGE0K-rDToWhz3mAdh-GUbtt0m6btLsmi37zOP_e_qmugPc7sMQU3S_8v2lQCLTuERZKcCp-Aw86ry0</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Haddad, Pierre S.</creator><creator>Musallam, Lina</creator><creator>Vallerand, Diane</creator><creator>Brault, Antoine</creator><creator>Ouchfoun, Meriem</creator><creator>Eid, Hoda M.</creator><creator>Arnason, John</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8991-3011</orcidid></search><sort><creationdate>20140101</creationdate><title>Lingonberry (Vaccinium vitis-idaea L.) 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Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes. In a previous study, the ethanol extract of berries of V. vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK) pathway. The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes. C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids) for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO) were used. Treatment began by adding V. vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg) for a subsequent period of 8 weeks (total HFD, 16 weeks). The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model. This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle. V. vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways. The results of the present study confirm that V. vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25013446</pmid><doi>10.1155/2014/645812</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8991-3011</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | AKT protein AMP AMP-activated protein kinase Antidiabetics Berries Blood glucose Diabetes mellitus Diabetes mellitus (non-insulin dependent) Ethanol Fatty liver Fruits Glucose High fat diet Insulin Insulin resistance Kinases Lipids Liver Muscles Obesity Plant extracts Rodents Skeletal muscle Steatosis Vaccinium vitis-idaea |
| title | Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity |
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