Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

Therapeutic decisions in cancer are generally guided by molecular biomarkers or, for some newer therapeutics, primary tumor genotype. However, because biomarkers or genotypes may change as new metastases emerge, circulating tumor cells (CTCs) from blood are being investigated for a role in guiding r...

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Veröffentlicht in:	BMC cancer 2014-06, Vol.14 (1), p.456-456, Article 456
Hauptverfasser:	Deng, Glenn, Krishnakumar, Sujatha, Powell, Ashley A, Zhang, Haiyu, Mindrinos, Michael N, Telli, Melinda L, Davis, Ronald W, Jeffrey, Stefanie S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow Bone Marrow - pathology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Class I Phosphatidylinositol 3-Kinases DNA Mutational Analysis Drug therapy Exons Female Humans Medical research Mutation Neoplasm Metastasis Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Phosphatidylinositol 3-Kinases - genetics Single-Cell Analysis - methods Studies
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