Aiolos Promotes Anchorage Independence by Silencing p66Shc Transcription in Cancer Cells

Anchorage of tissue cells to their physical environment is an obligate requirement for survival that is lost in mature hematopoietic and in transformed epithelial cells. Here we find that a lymphocyte lineage-restricted transcription factor, Aiolos, is frequently expressed in lung cancers and predic...

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Veröffentlicht in:	Cancer cell 2014-05, Vol.25 (5), p.575-589
Hauptverfasser:	Li, Xichuan, Xu, Zhao, Du, Wei, Zhang, Zhenfa, Wei, Yiliang, Wang, Hao, Zhu, Zhiyan, Qin, Litao, Wang, Lin, Niu, Qing, Zhao, Xiulan, Girard, Luc, Gong, Yimei, Ma, Zhenyi, Sun, Baocun, Yao, Zhi, Minna, John D., Terada, Lance S., Liu, Zhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Anoikis - genetics Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Cell Adhesion - genetics Cell Adhesion - physiology Cell Communication - physiology Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - genetics Chromatin - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Silencing Humans Ikaros Transcription Factor - metabolism Lung - metabolism Lung - pathology Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lymphopoiesis - genetics Promoter Regions, Genetic Shc Signaling Adaptor Proteins - genetics Src Homology 2 Domain-Containing, Transforming Protein 1 Transcription, Genetic
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