Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs

After the knock-out (KO) of α1,3 galactosyltransfease (Gal-T), the Hanganutziu-Deicher antigen became a major antigen of the "non-Gal antigen" that is implicated in subsequent xenograft rejection. For deletion of non-Gal antigen, we successfully produced zinc finger nuclease (ZFN)-mediated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2013-06, Vol.3 (1), p.1981-1981, Article 1981
Hauptverfasser:	Kwon, Deug-Nam, Lee, Kiho, Kang, Man-Jong, Choi, Yun-Jung, Park, Chankyu, Whyte, Jeffrey J., Brown, Alana N., Kim, Jae-Hwan, Samuel, Melissa, Mao, Jiude, Park, Kwang-Wook, Murphy, Clifton N., Prather, Randall S., Kim, Jin-Hoi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/334/2045 631/250/248 631/61/17/1511 631/61/51/2315 Amino Acid Sequence Animals Animals, Genetically Modified Antibiotics Antigens Base Sequence Binding Sites Deoxyribonucleic acid DNA DNA End-Joining Repair Female Fibroblasts - metabolism Gene Expression Gene Knockout Techniques Gene Order Gene Targeting Genetic Loci Genetic Vectors Genomes Homologous Recombination Homozygote Humanities and Social Sciences Karyotype Male Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Molecular Sequence Data multidisciplinary Mutation Phenotype Polymorphism, Single Nucleotide Protein Binding Risk reduction Science Swine Swine - genetics Xenografts Zinc finger proteins Zinc Fingers
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!