Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome
Irritable bowel syndrome(IBS)is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major role.The biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors,interacting with peripheral/central neuroendocri...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-06, Vol.20 (24), p.7570-7586 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Muscatello, Maria Rosaria A Bruno, Antonio Scimeca, Giuseppe Pandolfo, Gianluca Zoccali, Rocco A |
| description | Irritable bowel syndrome(IBS)is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major role.The biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors,interacting with peripheral/central neuroendocrine and immune changes,may induce symptoms of IBS,modulate symptom severity,influence illness experience and quality of life,and affect outcome.The present review focuses on the role of negative affects,including depression,anxiety,and anger,on pathogenesis and clinical expression of IBS.The potential role of the autonomic nervous system,stress-hormone system,and immune system in the pathophysiology of both negative affects and IBS are taken into account.Psychiatric comorbidity and subclinical variations in levels of depression,anxiety,and anger are further discussed in relation to the main pathophysiological and symptomatic correlates of IBS,such as sensorimotor functions,gut microbiota,inflammation/immunity,and symptom reporting. |
| doi_str_mv | 10.3748/wjg.v20.i24.7570 |
| format | Article |
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epidemiology</subject><subject>Anxiety - physiopathology</subject><subject>Anxiety - psychology</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Brain - physiopathology</subject><subject>Comorbidity</subject><subject>Depression</subject><subject>Depression - epidemiology</subject><subject>Depression - physiopathology</subject><subject>Depression - psychology</subject><subject>disorders</subject><subject>Epigenesis, Genetic</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Intestines - innervation</subject><subject>Irritable</subject><subject>Irritable Bowel Syndrome - epidemiology</subject><subject>Irritable Bowel Syndrome - genetics</subject><subject>Irritable Bowel Syndrome - physiopathology</subject><subject>Irritable Bowel Syndrome - psychology</subject><subject>Irritable Bowel Syndrome - therapy</subject><subject>Mood</subject><subject>Pituitary-Adrenal System - 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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Affect Anger Anxiety Anxiety - epidemiology Anxiety - physiopathology Anxiety - psychology Autonomic Nervous System - physiopathology Brain - physiopathology Comorbidity Depression Depression - epidemiology Depression - physiopathology Depression - psychology disorders Epigenesis, Genetic Genetic Predisposition to Disease Humans Hypothalamo-Hypophyseal System - physiopathology Intestines - innervation Irritable Irritable Bowel Syndrome - epidemiology Irritable Bowel Syndrome - genetics Irritable Bowel Syndrome - physiopathology Irritable Bowel Syndrome - psychology Irritable Bowel Syndrome - therapy Mood Pituitary-Adrenal System - physiopathology Prognosis Risk Factors Stress, Psychological - epidemiology Stress, Psychological - physiopathology Stress, Psychological - psychology Temperament Topic Highlight |
| title | Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome |
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