Phasevarions Mediate Epigenetic Regulation of Antimicrobial Susceptibility in Neisseria meningitidis

Phase variation is a common feature of host-adapted bacterial pathogens such as Neisseria meningitidis. Recently, we reported that this rapid on/off switching of gene expression occurs in DNA methyltransferases, altering expression in multiple genes via changes in global methylation. In the current...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-07, Vol.58 (7), p.4219-4221
Hauptverfasser:	JEN, Freda E.-C, SEIB, Kate L, JENNINGS, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ceftazidime - pharmacology Ciprofloxacin - pharmacology DNA (Cytosine-5-)-Methyltransferases DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation - genetics DNA, Bacterial - genetics Drug Resistance, Multiple, Bacterial Drug Resistance, Multiple, Bacterial - genetics Epigenesis, Genetic Gene Expression Regulation, Bacterial - genetics Mechanisms of Resistance Medical sciences Microbial Sensitivity Tests Neisseria meningitidis Neisseria meningitidis - drug effects Neisseria meningitidis - genetics Neisseria meningitidis - metabolism Pharmacology. Drug treatments
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