Liposome Encapsulation of Ciprofloxacin Improves Protection against Highly Virulent Francisella tularensis Strain Schu S4

Liposome-encapsulated ciprofloxacin for inhalation (CFI) was investigated as a putative postexposure therapeutic for two strains of Francisella tularensis. The efficacies of oral ciprofloxacin and intranasally instilled CFI could not be distinguished in a mouse model of infection with the F. tularen...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-06, Vol.58 (6), p.3053-3059
Hauptverfasser:	HAMBLIN, Karleigh A, ARMSTRONG, Stuart J, BARNES, Kay B, DAVIES, Carwyn, WONG, Jonathan P, BLANCHARD, James D, HARDING, Sarah V, SIMPSON, Andrew J. H, ATKINS, Helen S
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Administration, Intranasal Aerosols Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Vaccines - immunology Biological and medical sciences Biological Availability Ciprofloxacin Ciprofloxacin - administration & dosage Ciprofloxacin - pharmacokinetics Disease Models, Animal Experimental Therapeutics Female Francisella tularensis Francisella tularensis - drug effects Francisella tularensis - immunology Francisella tularensis - pathogenicity Liposomes Lung - immunology Lung - microbiology Medical sciences Mice Mice, Inbred BALB C Pharmacology. Drug treatments Survival Analysis Tularemia Tularemia - drug therapy Vaccines, Attenuated Vaccines, Attenuated - immunology Virulence
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