SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation

Mitotic spindle orientation relies on a complex dialog between the spindle microtubules and the cell cortex, in which F-actin has been recently implicated. Here, we report that the membrane-actin linkers ezrin/radixin/moesin (ERMs) are strongly and directly activated by the Ste20-like kinase at mito...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of Cell Biology 2014-06, Vol.205 (6), p.791-799
Hauptverfasser:	Machicoane, Mickael, de Frutos, Cristina A, Fink, Jenny, Rocancourt, Murielle, Lombardi, Yannis, Garel, Sonia, Piel, Matthieu, Echard, Arnaud
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear - analysis Antigens, Nuclear - metabolism Cell Division Cytoskeletal Proteins - metabolism HeLa Cells Humans Intracellular Signaling Peptides and Proteins - analysis Intracellular Signaling Peptides and Proteins - metabolism Kinases Life Sciences Membrane Proteins - metabolism Membranes Microfilament Proteins - metabolism Neurobiology Neurons and Cognition Nuclear Matrix-Associated Proteins - analysis Nuclear Matrix-Associated Proteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Rodents Spindle Apparatus - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!