Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats

Abstract Early brain injury (EBI), following subarachnoid hemorrhage (SAH), comprises blood–brain barrier (BBB) disruption and consequent edema formation. Peripheral leukocytes can infiltrate the injured brain, thereby aggravating BBB leakage and neuroinflammation. Thus, anti-inflammatory pharmacoth...

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Veröffentlicht in:	Journal of the neurological sciences 2014-07, Vol.342 (1), p.101-106
Hauptverfasser:	Fujii, Mutsumi, Sherchan, Prativa, Krafft, Paul R, Rolland, William B, Soejima, Yoshiteru, Zhang, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Bornanes - pharmacology Brain - drug effects Brain - metabolism Brain - physiopathology Brain edema Brain Edema - complications Brain Edema - drug therapy Brain Edema - physiopathology Cannabinoid Receptor Agonists - pharmacology Cannabinoid Receptor Agonists - therapeutic use Cannabinoid Receptor Antagonists - pharmacology Cannabinoid type 2 receptor Cannabinoids - pharmacology Cannabinoids - therapeutic use Chemotaxis, Leukocyte - drug effects E-Selectin - biosynthesis E-Selectin - drug effects Early brain injury Gene Expression Regulation - drug effects JWH133 Leukocytes - cytology Leukocytes - drug effects Male Neurology Peroxidase - biosynthesis Peroxidase - drug effects Pyrazoles - pharmacology Rats Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - physiology Subarachnoid hemorrhage Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - drug therapy Transforming Growth Factor beta1 - biosynthesis Transforming Growth Factor beta1 - drug effects Zonula Occludens-1 Protein - biosynthesis Zonula Occludens-1 Protein - drug effects
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