Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development

Dorsal spinal cord neurons receive and integrate somatosensory information provided by neurons located in dorsal root ganglia. Here we demonstrate that dorsal spinal neurons require the Krüppel-C(2)H(2) zinc-finger transcription factor Bcl11a for terminal differentiation and morphogenesis. The disru...

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Veröffentlicht in:	Development (Cambridge) 2012-05, Vol.139 (10), p.1831-1841
Hauptverfasser:	John, Anita, Brylka, Heike, Wiegreffe, Christoph, Simon, Ruth, Liu, Pentao, Jüttner, René, Crenshaw, 3rd, E Bryan, Luyten, Frank P, Jenkins, Nancy A, Copeland, Neal G, Birchmeier, Carmen, Britsch, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Differentiation - genetics Cell Differentiation - physiology Cells, Cultured Chromatin Immunoprecipitation Circuits Differentiation Dorsal horn Dorsal root ganglia Electrophysiology Frizzled-related protein 3 Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Gene expression Genetic analysis In Situ Hybridization Information processing Innervation Mice Mice, Knockout Morphogenesis Morphogenesis - genetics Morphogenesis - physiology Neurons - cytology Neurons - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Real-Time Polymerase Chain Reaction Sensory neurons Sensory Receptor Cells - cytology Sensory Receptor Cells - metabolism Spinal cord Spinal Cord - cytology Spinal Cord - metabolism Transcription factors Wnt protein
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