MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice

Transgenic sickle mice expressing βS hemoglobin have activated vascular endothelium in multiple organs that exhibits enhanced expression of NF-ĸB and adhesion molecules and promotes microvascular stasis in sickle, but not normal, mice in response to hypoxia/reoxygenation (H/R), or heme. Induction of...

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Veröffentlicht in:	Blood 2013-10, Vol.122 (15), p.2757-2764
Hauptverfasser:	Belcher, John D., Young, Mark, Chen, Chunsheng, Nguyen, Julia, Burhop, Kenneth, Tran, Phuc, Vercellotti, Gregory M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - drug therapy Anemia, Sickle Cell - metabolism Anemia, Sickle Cell - mortality Animals Carbon Monoxide - metabolism Carbon Monoxide - pharmacology Disease Models, Animal Female Guaiacol - analogs & derivatives Heme Oxygenase-1 - metabolism Hemin - metabolism Hemin - pharmacology Hemoglobins - metabolism Hemoglobins - pharmacology Humans Inflammation - drug therapy Inflammation - metabolism Inflammation - mortality Male Maleimides - metabolism Maleimides - pharmacology Membrane Proteins - metabolism Mice Mice, Transgenic Microcirculation - drug effects Microcirculation - physiology NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Polyethylene Glycols - metabolism Polyethylene Glycols - pharmacology Vascular Biology Vasculitis - drug therapy Vasculitis - metabolism Vasculitis - mortality
Online-Zugang:	Volltext
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