Effect of Salsalate on Insulin Action, Secretion, and Clearance in Nondiabetic, Insulin-Resistant Individuals: A Randomized, Placebo-Controlled Study
Salsalate treatment has been shown to improve glucose homeostasis, but the mechanism remains unclear. The aim of this study was to evaluate the effect of salsalate treatment on insulin action, secretion, and clearance rate in nondiabetic individuals with insulin resistance. This was a randomized (2:...
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| Veröffentlicht in: | Diabetes care 2014-07, Vol.37 (7), p.1944-1950 |
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| container_title | Diabetes care |
| container_volume | 37 |
| creator | KIM, Sun H LIU, Alice ARIEL, Danit ABBASI, Fahim LAMENDOLA, Cindy GROVE, Kaylene TOMASSO, Vanessa OCHOA, Hector REAVEN, Gerald |
| description | Salsalate treatment has been shown to improve glucose homeostasis, but the mechanism remains unclear. The aim of this study was to evaluate the effect of salsalate treatment on insulin action, secretion, and clearance rate in nondiabetic individuals with insulin resistance.
This was a randomized (2:1), single-blind, placebo-controlled study of salsalate (3.5 g daily for 4 weeks) in nondiabetic individuals with insulin resistance. All individuals had measurement of glucose tolerance (75-g oral glucose tolerance test), steady-state plasma glucose (SSPG; insulin suppression test), and insulin secretion and clearance rate (graded-glucose infusion test) before and after treatment.
Forty-one individuals were randomized to salsalate (n = 27) and placebo (n = 14). One individual from each group discontinued the study. Salsalate improved fasting (% mean change -7% [95% CI -10 to -14] vs. 1% [-3 to 5], P = 0.005) but not postprandial glucose concentration compared with placebo. Salsalate also lowered fasting triglyceride concentration (-25% [-34 to -15] vs. -6% [-26 to 14], P = 0.04). Salsalate had no effect on SSPG concentration or insulin secretion rate but significantly decreased insulin clearance rate compared with placebo (-23% [-30 to -16] vs. 3% [-10 to 15], P < 0.001). Salsalate was well tolerated, but four individuals needed a dose reduction due to symptoms.
Salsalate treatment in nondiabetic, insulin-resistant individuals improved fasting, but not postprandial, glucose and triglyceride concentration. These improvements were associated with a decrease in insulin clearance rate without change in insulin action or insulin secretion. |
| doi_str_mv | 10.2337/dc13-2977 |
| format | Article |
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This was a randomized (2:1), single-blind, placebo-controlled study of salsalate (3.5 g daily for 4 weeks) in nondiabetic individuals with insulin resistance. All individuals had measurement of glucose tolerance (75-g oral glucose tolerance test), steady-state plasma glucose (SSPG; insulin suppression test), and insulin secretion and clearance rate (graded-glucose infusion test) before and after treatment.
Forty-one individuals were randomized to salsalate (n = 27) and placebo (n = 14). One individual from each group discontinued the study. Salsalate improved fasting (% mean change -7% [95% CI -10 to -14] vs. 1% [-3 to 5], P = 0.005) but not postprandial glucose concentration compared with placebo. Salsalate also lowered fasting triglyceride concentration (-25% [-34 to -15] vs. -6% [-26 to 14], P = 0.04). Salsalate had no effect on SSPG concentration or insulin secretion rate but significantly decreased insulin clearance rate compared with placebo (-23% [-30 to -16] vs. 3% [-10 to 15], P < 0.001). Salsalate was well tolerated, but four individuals needed a dose reduction due to symptoms.
Salsalate treatment in nondiabetic, insulin-resistant individuals improved fasting, but not postprandial, glucose and triglyceride concentration. These improvements were associated with a decrease in insulin clearance rate without change in insulin action or insulin secretion.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc13-2977</identifier><identifier>PMID: 24963111</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adult ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Biological and medical sciences ; Blood Glucose - drug effects ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Fasting ; Female ; Glucose ; Glucose Tolerance Test ; Homeostasis ; Humans ; Insulin - metabolism ; Insulin Resistance ; Insulin Secretion ; Male ; Medical sciences ; Medical treatment ; Metabolic diseases ; Middle Aged ; Pathophysiology/Complications ; Postprandial Period - drug effects ; Salicylates - pharmacology ; Single-Blind Method ; Triglycerides - blood</subject><ispartof>Diabetes care, 2014-07, Vol.37 (7), p.1944-1950</ispartof><rights>2015 INIST-CNRS</rights><rights>2014 by the American Diabetes Association.</rights><rights>Copyright American Diabetes Association Jul 2014</rights><rights>2014 by the American Diabetes Association. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-5bffcfcebaf98094c8f414aa2842a547dcd007e869f16f75e681bd3524aec8eb3</citedby><cites>FETCH-LOGICAL-c433t-5bffcfcebaf98094c8f414aa2842a547dcd007e869f16f75e681bd3524aec8eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28677220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24963111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIM, Sun H</creatorcontrib><creatorcontrib>LIU, Alice</creatorcontrib><creatorcontrib>ARIEL, Danit</creatorcontrib><creatorcontrib>ABBASI, Fahim</creatorcontrib><creatorcontrib>LAMENDOLA, Cindy</creatorcontrib><creatorcontrib>GROVE, Kaylene</creatorcontrib><creatorcontrib>TOMASSO, Vanessa</creatorcontrib><creatorcontrib>OCHOA, Hector</creatorcontrib><creatorcontrib>REAVEN, Gerald</creatorcontrib><title>Effect of Salsalate on Insulin Action, Secretion, and Clearance in Nondiabetic, Insulin-Resistant Individuals: A Randomized, Placebo-Controlled Study</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Salsalate treatment has been shown to improve glucose homeostasis, but the mechanism remains unclear. The aim of this study was to evaluate the effect of salsalate treatment on insulin action, secretion, and clearance rate in nondiabetic individuals with insulin resistance.
This was a randomized (2:1), single-blind, placebo-controlled study of salsalate (3.5 g daily for 4 weeks) in nondiabetic individuals with insulin resistance. All individuals had measurement of glucose tolerance (75-g oral glucose tolerance test), steady-state plasma glucose (SSPG; insulin suppression test), and insulin secretion and clearance rate (graded-glucose infusion test) before and after treatment.
Forty-one individuals were randomized to salsalate (n = 27) and placebo (n = 14). One individual from each group discontinued the study. Salsalate improved fasting (% mean change -7% [95% CI -10 to -14] vs. 1% [-3 to 5], P = 0.005) but not postprandial glucose concentration compared with placebo. Salsalate also lowered fasting triglyceride concentration (-25% [-34 to -15] vs. -6% [-26 to 14], P = 0.04). Salsalate had no effect on SSPG concentration or insulin secretion rate but significantly decreased insulin clearance rate compared with placebo (-23% [-30 to -16] vs. 3% [-10 to 15], P < 0.001). Salsalate was well tolerated, but four individuals needed a dose reduction due to symptoms.
Salsalate treatment in nondiabetic, insulin-resistant individuals improved fasting, but not postprandial, glucose and triglyceride concentration. These improvements were associated with a decrease in insulin clearance rate without change in insulin action or insulin secretion.</description><subject>Adult</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose Tolerance Test</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin Resistance</subject><subject>Insulin Secretion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Pathophysiology/Complications</subject><subject>Postprandial Period - drug effects</subject><subject>Salicylates - pharmacology</subject><subject>Single-Blind Method</subject><subject>Triglycerides - blood</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1rFDEUhoModq1e-AckIILCjuZrZhIvhGWpWigqXb0OmeREU7JJO5kp1P_h_zXLbuvHVULOcx7e8CL0lJLXjPP-jbOUN0z1_T20oIq3TdsKeR8tCBWqaZViR-hRKReEECGkfIiOmFAdp5Qu0K8T78FOOHu8MbGYaCbAOeHTVOYYEl7ZKeS0xBuwI-yvJjm8jmBGkyzgynzKyQUz1LFd3i4251BCmUya6osL18HNVf8Wr_B53c_b8BPcEn-JxsKQm3VO05hjBIc30-xuHqMHvuLw5HAeo2_vT76uPzZnnz-crldnjRWcT007eG99NRivJFHCSi-oMIZJwUwremcdIT3ITnna-b6FTtLB8ZYJA1bCwI_Ru733ch624CzUGCbqyzFszXijswn630kKP_T3fK0F6XquWBW8PAjGfDVDmfQ2FAsxmgR5Lpq2gvSUKkkr-vw_9CLPY6rf21GMVZ8glXq1p-yYSxnB34WhRO_K1ruy9a7syj77O_0dedtuBV4cAFOsiX7XWCh_ONn1PWOE_waDE7QA</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>KIM, Sun H</creator><creator>LIU, Alice</creator><creator>ARIEL, Danit</creator><creator>ABBASI, Fahim</creator><creator>LAMENDOLA, Cindy</creator><creator>GROVE, Kaylene</creator><creator>TOMASSO, Vanessa</creator><creator>OCHOA, Hector</creator><creator>REAVEN, Gerald</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140701</creationdate><title>Effect of Salsalate on Insulin Action, Secretion, and Clearance in Nondiabetic, Insulin-Resistant Individuals: A Randomized, Placebo-Controlled Study</title><author>KIM, Sun H ; LIU, Alice ; ARIEL, Danit ; ABBASI, Fahim ; LAMENDOLA, Cindy ; GROVE, Kaylene ; TOMASSO, Vanessa ; OCHOA, Hector ; REAVEN, Gerald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-5bffcfcebaf98094c8f414aa2842a547dcd007e869f16f75e681bd3524aec8eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose Tolerance Test</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin Resistance</topic><topic>Insulin Secretion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Pathophysiology/Complications</topic><topic>Postprandial Period - drug effects</topic><topic>Salicylates - pharmacology</topic><topic>Single-Blind Method</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIM, Sun H</creatorcontrib><creatorcontrib>LIU, Alice</creatorcontrib><creatorcontrib>ARIEL, Danit</creatorcontrib><creatorcontrib>ABBASI, Fahim</creatorcontrib><creatorcontrib>LAMENDOLA, Cindy</creatorcontrib><creatorcontrib>GROVE, Kaylene</creatorcontrib><creatorcontrib>TOMASSO, Vanessa</creatorcontrib><creatorcontrib>OCHOA, Hector</creatorcontrib><creatorcontrib>REAVEN, Gerald</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIM, Sun H</au><au>LIU, Alice</au><au>ARIEL, Danit</au><au>ABBASI, Fahim</au><au>LAMENDOLA, Cindy</au><au>GROVE, Kaylene</au><au>TOMASSO, Vanessa</au><au>OCHOA, Hector</au><au>REAVEN, Gerald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Salsalate on Insulin Action, Secretion, and Clearance in Nondiabetic, Insulin-Resistant Individuals: A Randomized, Placebo-Controlled Study</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>37</volume><issue>7</issue><spage>1944</spage><epage>1950</epage><pages>1944-1950</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Salsalate treatment has been shown to improve glucose homeostasis, but the mechanism remains unclear. The aim of this study was to evaluate the effect of salsalate treatment on insulin action, secretion, and clearance rate in nondiabetic individuals with insulin resistance.
This was a randomized (2:1), single-blind, placebo-controlled study of salsalate (3.5 g daily for 4 weeks) in nondiabetic individuals with insulin resistance. All individuals had measurement of glucose tolerance (75-g oral glucose tolerance test), steady-state plasma glucose (SSPG; insulin suppression test), and insulin secretion and clearance rate (graded-glucose infusion test) before and after treatment.
Forty-one individuals were randomized to salsalate (n = 27) and placebo (n = 14). One individual from each group discontinued the study. Salsalate improved fasting (% mean change -7% [95% CI -10 to -14] vs. 1% [-3 to 5], P = 0.005) but not postprandial glucose concentration compared with placebo. Salsalate also lowered fasting triglyceride concentration (-25% [-34 to -15] vs. -6% [-26 to 14], P = 0.04). Salsalate had no effect on SSPG concentration or insulin secretion rate but significantly decreased insulin clearance rate compared with placebo (-23% [-30 to -16] vs. 3% [-10 to 15], P < 0.001). Salsalate was well tolerated, but four individuals needed a dose reduction due to symptoms.
Salsalate treatment in nondiabetic, insulin-resistant individuals improved fasting, but not postprandial, glucose and triglyceride concentration. These improvements were associated with a decrease in insulin clearance rate without change in insulin action or insulin secretion.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>24963111</pmid><doi>10.2337/dc13-2977</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2014-07, Vol.37 (7), p.1944-1950 |
| issn | 0149-5992 1935-5548 |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Blood Glucose - drug effects Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fasting Female Glucose Glucose Tolerance Test Homeostasis Humans Insulin - metabolism Insulin Resistance Insulin Secretion Male Medical sciences Medical treatment Metabolic diseases Middle Aged Pathophysiology/Complications Postprandial Period - drug effects Salicylates - pharmacology Single-Blind Method Triglycerides - blood |
| title | Effect of Salsalate on Insulin Action, Secretion, and Clearance in Nondiabetic, Insulin-Resistant Individuals: A Randomized, Placebo-Controlled Study |
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