The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth

Rap1 is a Ras family GTPase with a well documented role in ERK/MAP kinase signaling and integrin activation. Stimulation of the G-protein-coupled receptor PAR-1 with thrombin in human 1321N1 glioblastoma cells led to a robust increase in Rap1 activation. This response was sustained for up to 6 h and...

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Veröffentlicht in:	The Journal of biological chemistry 2014-06, Vol.289 (25), p.17689-17698
Hauptverfasser:	Sayyah, Jacqueline, Bartakova, Alena, Nogal, Nekeisha, Quilliam, Lawrence A., Stupack, Dwayne G., Brown, Joan Heller
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Proliferation Cell Signaling G-protein-coupled Receptor (GPCR) Gene Expression Regulation, Neoplastic Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Heterografts Humans Integrin Integrin beta1 - genetics Integrin beta1 - metabolism Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Transplantation Rap1 rap1 GTP-Binding Proteins - biosynthesis rap1 GTP-Binding Proteins - genetics rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Signal Transduction Small GTPase Thrombin Thrombin - genetics Thrombin - metabolism
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