Expression of LacdiNAc Groups on N-Glycans among Human Tumors Is Complex
Aberrant glycosylation of proteins and lipids is one of the characteristic features of malignantly transformed cells. The GalNAcβ1 → 4GlcNAc (LacdiNAc or LDN) group at the nonreducing termini of both N- and O-glycans is not generally found in mammalian cells. We previously showed that the expression...
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| description | Aberrant glycosylation of proteins and lipids is one of the characteristic features of malignantly transformed cells. The GalNAcβ1 → 4GlcNAc (LacdiNAc or LDN) group at the nonreducing termini of both N- and O-glycans is not generally found in mammalian cells. We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer. In contrast, the enhanced expression of the LacdiNAc group has been shown to be associated with the progression of human prostate, ovarian, and pancreatic cancers. Therefore, the expression of the disaccharide group appears to be dependent on types of tumors. The mechanism of formation of the LacdiNAc group in human tumors and cancer cells has been studied, and two β4-N-acetylgalacto-saminyltransferases (β4GalNAcTs), β4GalNAcT3 and β4GalNAcT4, have been shown to be involved in the biosynthesis of this disaccharide group in a tissue-dependent manner. Transfection of the β4GalNAcT3 gene brought about significant changes in the malignant phenotypes of human neuroblastoma, indicating that this disaccharide group is important for suppressing the tumor growth. |
| doi_str_mv | 10.1155/2014/981627 |
| format | Article |
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The GalNAcβ1 → 4GlcNAc (LacdiNAc or LDN) group at the nonreducing termini of both N- and O-glycans is not generally found in mammalian cells. We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer. In contrast, the enhanced expression of the LacdiNAc group has been shown to be associated with the progression of human prostate, ovarian, and pancreatic cancers. Therefore, the expression of the disaccharide group appears to be dependent on types of tumors. The mechanism of formation of the LacdiNAc group in human tumors and cancer cells has been studied, and two β4-N-acetylgalacto-saminyltransferases (β4GalNAcTs), β4GalNAcT3 and β4GalNAcT4, have been shown to be involved in the biosynthesis of this disaccharide group in a tissue-dependent manner. Transfection of the β4GalNAcT3 gene brought about significant changes in the malignant phenotypes of human neuroblastoma, indicating that this disaccharide group is important for suppressing the tumor growth.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/981627</identifier><identifier>PMID: 25003135</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Analysis ; Bioengineering ; Biosynthesis ; Breast cancer ; Care and treatment ; Cell adhesion & migration ; Cell Transformation, Neoplastic - metabolism ; Cell Transformation, Neoplastic - pathology ; Colleges & universities ; Complications and side effects ; Development and progression ; Gene expression ; Glycoproteins ; Humans ; Influence ; Lactose - analogs & derivatives ; Lactose - metabolism ; Neoplasms - metabolism ; Neoplasms - pathology ; Pancreatic cancer ; Polysaccharides - metabolism ; Prostate cancer ; Review ; Rodents ; Tumors</subject><ispartof>BioMed research international, 2014, Vol.2014 (2014), p.1-7</ispartof><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Kiyoko Hirano et al. Kiyoko Hirano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Kiyoko Hirano et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-348d9288b0f975679cd1131ccd80d1fb88b6d7fdef0899e63430c752df7e6db93</citedby><cites>FETCH-LOGICAL-c558t-348d9288b0f975679cd1131ccd80d1fb88b6d7fdef0899e63430c752df7e6db93</cites><orcidid>0000-0001-5505-1030 ; 0000-0002-7408-9306</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066867/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066867/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,4025,27928,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25003135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirano, Kiyoko</creatorcontrib><creatorcontrib>Matsuda, Akio</creatorcontrib><creatorcontrib>Shirai, Takashi</creatorcontrib><creatorcontrib>Furukawa, Kiyoshi</creatorcontrib><title>Expression of LacdiNAc Groups on N-Glycans among Human Tumors Is Complex</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Aberrant glycosylation of proteins and lipids is one of the characteristic features of malignantly transformed cells. The GalNAcβ1 → 4GlcNAc (LacdiNAc or LDN) group at the nonreducing termini of both N- and O-glycans is not generally found in mammalian cells. We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer. In contrast, the enhanced expression of the LacdiNAc group has been shown to be associated with the progression of human prostate, ovarian, and pancreatic cancers. Therefore, the expression of the disaccharide group appears to be dependent on types of tumors. The mechanism of formation of the LacdiNAc group in human tumors and cancer cells has been studied, and two β4-N-acetylgalacto-saminyltransferases (β4GalNAcTs), β4GalNAcT3 and β4GalNAcT4, have been shown to be involved in the biosynthesis of this disaccharide group in a tissue-dependent manner. 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The GalNAcβ1 → 4GlcNAc (LacdiNAc or LDN) group at the nonreducing termini of both N- and O-glycans is not generally found in mammalian cells. We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer. In contrast, the enhanced expression of the LacdiNAc group has been shown to be associated with the progression of human prostate, ovarian, and pancreatic cancers. Therefore, the expression of the disaccharide group appears to be dependent on types of tumors. The mechanism of formation of the LacdiNAc group in human tumors and cancer cells has been studied, and two β4-N-acetylgalacto-saminyltransferases (β4GalNAcTs), β4GalNAcT3 and β4GalNAcT4, have been shown to be involved in the biosynthesis of this disaccharide group in a tissue-dependent manner. Transfection of the β4GalNAcT3 gene brought about significant changes in the malignant phenotypes of human neuroblastoma, indicating that this disaccharide group is important for suppressing the tumor growth.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25003135</pmid><doi>10.1155/2014/981627</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5505-1030</orcidid><orcidid>https://orcid.org/0000-0002-7408-9306</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Bioengineering Biosynthesis Breast cancer Care and treatment Cell adhesion & migration Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Colleges & universities Complications and side effects Development and progression Gene expression Glycoproteins Humans Influence Lactose - analogs & derivatives Lactose - metabolism Neoplasms - metabolism Neoplasms - pathology Pancreatic cancer Polysaccharides - metabolism Prostate cancer Review Rodents Tumors |
| title | Expression of LacdiNAc Groups on N-Glycans among Human Tumors Is Complex |
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