The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction

Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes...

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Veröffentlicht in:	Nucleic acids research 2014-06, Vol.42 (11), p.7113-7131
Hauptverfasser:	Jackson, Andrew P, Otto, Thomas D, Darby, Alistair, Ramaprasad, Abhinay, Xia, Dong, Echaide, Ignacio Eduardo, Farber, Marisa, Gahlot, Sunayna, Gamble, John, Gupta, Dinesh, Gupta, Yask, Jackson, Louise, Malandrin, Laurence, Malas, Tareq B, Moussa, Ehab, Nair, Mridul, Reid, Adam J, Sanders, Mandy, Sharma, Jyotsna, Tracey, Alan, Quail, Mike A, Weir, William, Wastling, Jonathan M, Hall, Neil, Willadsen, Peter, Lingelbach, Klaus, Shiels, Brian, Tait, Andy, Berriman, Matt, Allred, David R, Pain, Arnab
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigenic Variation Babesia Babesia - genetics Chromosome Breakpoints Evolution, Molecular Gene regulation, Chromatin and Epigenetics Genes, Protozoan Genome, Protozoan Host-Parasite Interactions - genetics Life Sciences Protozoan Proteins - genetics Recombination, Genetic
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