RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events

TLRs 7 and 8 are pattern recognition receptors controlling antiviral host defense or autoimmune diseases. Apart from foreign and host RNA, synthetic RNA oligoribonucleotides (ORN) or small molecules of the imidazoquinoline family activate TLR7 and 8 and are being developed as therapeutic agonists. T...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-06, Vol.192 (12), p.5963-5973
Hauptverfasser:	Colak, Elif, Leslie, Alasdair, Zausmer, Kieran, Khatamzas, Elham, Kubarenko, Andriy V, Pichulik, Tica, Klimosch, Sascha N, Mayer, Alice, Siggs, Owen, Hector, Andreas, Fischer, Roman, Klesser, Benedikt, Rautanen, Anna, Frank, Martin, Hill, Adrian V S, Manoury, Bénédicte, Beutler, Bruce, Hartl, Dominik, Simmons, Alison, Weber, Alexander N R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals HEK293 Cells Humans Mice Oligoribonucleotides - chemistry Oligoribonucleotides - pharmacology Protein Structure, Tertiary Quinolinium Compounds - chemistry Quinolinium Compounds - pharmacology RNA - chemistry RNA - pharmacology Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - immunology Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - immunology Toll-Like Receptor 8 - genetics Toll-Like Receptor 8 - immunology
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