Glycosylation, Hypogammaglobulinemia, and Resistance to Viral Infections

In two siblings, a congenital disorder of glycosylation (CDG-IIb) was shown to lead to severe hypogammaglobulinemia but paradoxically impaired viral replication. Most proteins, including immunoglobulins, human virus receptors, and viral-coded proteins, are post-translationally modified with sugars o...

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Veröffentlicht in:	The New England journal of medicine 2014-04, Vol.370 (17), p.1615-1625
Hauptverfasser:	Sadat, Mohammed A, Moir, Susan, Chun, Tae-Wook, Lusso, Paolo, Kaplan, Gerardo, Wolfe, Lynne, Memoli, Matthew J, He, Miao, Vega, Hugo, Kim, Leo J.Y, Huang, Yan, Hussein, Nadia, Nievas, Elma, Mitchell, Raquel, Garofalo, Mary, Louie, Aaron, Ireland, Derek C, Grunes, Claire, Cimbro, Raffaello, Patel, Vyomesh, Holzapfel, Genevieve, Salahuddin, Daniel, Bristol, Tyler, Adams, David, Marciano, Beatriz E, Hegde, Madhuri, Li, Yuxing, Calvo, Katherine R, Stoddard, Jennifer, Justement, J. Shawn, Jacques, Jerome, Long Priel, Debra A, Murray, Danielle, Sun, Peter, Kuhns, Douglas B, Boerkoel, Cornelius F, Chiorini, John A, Di Pasquale, Giovanni, Verthelyi, Daniela, Rosenzweig, Sergio D
Format:	Artikel
Sprache:	eng
Schlagworte:	Agammaglobulinemia - genetics Agammaglobulinemia - immunology alpha-Glucosidases - genetics Antibodies, Viral - blood Child Congenital diseases Congenital Disorders of Glycosylation - genetics Congenital Disorders of Glycosylation - immunology Congenital Disorders of Glycosylation - metabolism Disease Resistance - genetics Endoplasmic reticulum Female Glycosylation Humans Hypogammaglobulinemia Immunoglobulins Immunoglobulins - metabolism Immunology Male Mannosyl-oligosaccharide glucosidase N-glycans Neurological complications Phenotypes Polysaccharides Viral infections Virus Diseases - immunology
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