Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome

Obesity is associated with vascular diseases that are often attributed to vascular oxidative stress. We tested the hypothesis that vascular oxidative stress could induce obesity. We previously developed mice that overexpress p22phox in vascular smooth muscle, tg(sm/p22phox), which have increased vas...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2014-07, Vol.63 (7), p.2344-2355
Hauptverfasser:	YOUN, Ji-Youn, KIN LUNG SIU, LOB, Heinrich E, ITANI, Hana, HARRISON, David G, HUA CAI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis - genetics Animals Biological and medical sciences Cytochrome b Group - genetics Cytochrome b Group - metabolism Diabetes. Impaired glucose tolerance Diet, High-Fat Drug Resistance - genetics Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Leptin - pharmacology Male Medical sciences Metabolic diseases Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Miscellaneous Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Musculoskeletal system NADPH Oxidases - genetics NADPH Oxidases - metabolism Obesity Obesity - complications Obesity - metabolism Obesity Studies Other metabolic disorders Oxidative stress Oxidative Stress - physiology Reactive Oxygen Species - adverse effects Reactive Oxygen Species - metabolism Rodents Smooth muscle Vascular Diseases - etiology Vascular Diseases - metabolism Weight
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