VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues
We read with a great interest the recent work of Deli and colleagues. in the World Journal of Gastroenterology reporting vascular endothelial growth factor （VEGF） expression in hepatocellular carcinoma （HCC） and cirrhotic liver tissues. This well-documented work shows that VEGF was significantly hig...
Gespeichert in:
| Veröffentlicht in: | World journal of gastroenterology : WJG 2006-02, Vol.12 (5), p.830-831 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 831 |
|---|---|
| container_issue | 5 |
| container_start_page | 830 |
| container_title | World journal of gastroenterology : WJG |
| container_volume | 12 |
| creator | Mathonnet, Muriel Descottes, Bernard Valleix, Denis Labrousse, François Denizot, Yves |
| description | We read with a great interest the recent work of Deli and colleagues. in the World Journal of Gastroenterology reporting vascular endothelial growth factor （VEGF） expression in hepatocellular carcinoma （HCC） and cirrhotic liver tissues. This well-documented work shows that VEGF was significantly higher in surrounding cirrhotic liver tissues than in HCC. Authors assessed VEGF expression using immunohistochemistry. The immunohistochemical staining is an efficient tool to assess the percentage of cells stained positively for VEGF but is not really efficient to estimate their true VEGF content. Evaluation of the VEGF protein by an enzyme-linked immunosorbent assay 0ELISA） has been reported, by us and others, to be an efficient tool in order to assess tissue VEGF expression. We have, thus, tested whether the ELISA method might be an efficient tool in order to confirm data reporting higher amounts of VEGF in surrounding cirrhotic liver tissues than in HCC. Deli and colleagues. also correctly pointed out that basic fibroblast growth factor （bFGF） has been reported to act cooperatively on VEGF expression. We have, thus, also assessed bFGF tissue levels in order to search for a putative link between VEGF and bFGF levels in cirrhotic tissues. |
| doi_str_mv | 10.3748/wjg.v12.i5.830 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4066145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>21353282</cqvip_id><wanfj_id>wjg200605032</wanfj_id><sourcerecordid>wjg200605032</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-ca55297ee081bae529c03014ca3e0e870cd41877e3af8fec7e04107d0ad1e1623</originalsourceid><addsrcrecordid>eNpdkc2L2zAQxUVp6abbXnssppTCHuyOJMtSLoVl2d0UAr20vQpFHjtKHSkr2Vn631cmYftxkpB-83jzHiFvKVRc1urT466vjpRVTlSKwzOyYIwuS6ZqeE4WFECWS87kBXmV0g6AcS7YS3JBG8EoA7Ugqx-393eF88UWD2YMFodhGkwsrInW-bA3hfFtkaYYw-Rb5_vCuhi3YXS2GNwRYzG6lCZMr8mLzgwJ35zPS_L97vbbzapcf73_cnO9Lm0t1VhaIwRbSkRQdGMw3y1woLU1HAGVBNvWVEmJ3HSqQysRagqyBdNSpA3jl-TzSfcwbfbYWvRjNIM-RLc38ZcOxul_f7zb6j4cdQ1NQ2uRBa5OAtv_xlbXaz2_Qc4JWC2ONLMfTuyj8Z3xvd6FKfq8ns65M4AGBPDZ08ezpxgechaj3rs0R2k8hinpRsrcCFMZrE6gjSGliN2TAQp67nPW1blP7YTOfeaBd39v-wc_F5iB92fFbfD9Qy5Ib4z92bkBNaNccKYY_w3cWagS</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67728428</pqid></control><display><type>article</type><title>VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Mathonnet, Muriel ; Descottes, Bernard ; Valleix, Denis ; Labrousse, François ; Denizot, Yves</creator><creatorcontrib>Mathonnet, Muriel ; Descottes, Bernard ; Valleix, Denis ; Labrousse, François ; Denizot, Yves</creatorcontrib><description>We read with a great interest the recent work of Deli and colleagues. in the World Journal of Gastroenterology reporting vascular endothelial growth factor （VEGF） expression in hepatocellular carcinoma （HCC） and cirrhotic liver tissues. This well-documented work shows that VEGF was significantly higher in surrounding cirrhotic liver tissues than in HCC. Authors assessed VEGF expression using immunohistochemistry. The immunohistochemical staining is an efficient tool to assess the percentage of cells stained positively for VEGF but is not really efficient to estimate their true VEGF content. Evaluation of the VEGF protein by an enzyme-linked immunosorbent assay 0ELISA） has been reported, by us and others, to be an efficient tool in order to assess tissue VEGF expression. We have, thus, tested whether the ELISA method might be an efficient tool in order to confirm data reporting higher amounts of VEGF in surrounding cirrhotic liver tissues than in HCC. Deli and colleagues. also correctly pointed out that basic fibroblast growth factor （bFGF） has been reported to act cooperatively on VEGF expression. We have, thus, also assessed bFGF tissue levels in order to search for a putative link between VEGF and bFGF levels in cirrhotic tissues.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v12.i5.830</identifier><identifier>PMID: 16521208</identifier><language>eng</language><publisher>United States: Service de Chirurgie Digestive, Endocrinienne et Générale, CHU Dupuytren, Limoges, France%Service de Chirurgie Viscérale et Transplantation, CHU Dupuytren, Limoges, France%Service d'Anatomo-Pathologie, CHU Dupuytren, Limoges, France%UMR CNRS 6101, Faculté de Médecine, Limoges,France</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular ; Carcinoma, Hepatocellular - metabolism ; Female ; Fibroblast Growth Factor 2 ; Fibroblast Growth Factor 2 - metabolism ; Humans ; Immunology ; Letters To The Editor ; Life Sciences ; Liver Cirrhosis ; Liver Cirrhosis - metabolism ; Liver Neoplasms ; Liver Neoplasms - metabolism ; Male ; Middle Aged ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor A - metabolism ; 病理机制 ; 肝硬化 ; 肝细胞癌 ; 血管内皮生长因子</subject><ispartof>World journal of gastroenterology : WJG, 2006-02, Vol.12 (5), p.830-831</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2006 Baishideng Publishing Group Co., Limited. All rights reserved. 2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-ca55297ee081bae529c03014ca3e0e870cd41877e3af8fec7e04107d0ad1e1623</citedby><cites>FETCH-LOGICAL-c478t-ca55297ee081bae529c03014ca3e0e870cd41877e3af8fec7e04107d0ad1e1623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066145/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066145/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16521208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00020245$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Mathonnet, Muriel</creatorcontrib><creatorcontrib>Descottes, Bernard</creatorcontrib><creatorcontrib>Valleix, Denis</creatorcontrib><creatorcontrib>Labrousse, François</creatorcontrib><creatorcontrib>Denizot, Yves</creatorcontrib><title>VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>We read with a great interest the recent work of Deli and colleagues. in the World Journal of Gastroenterology reporting vascular endothelial growth factor （VEGF） expression in hepatocellular carcinoma （HCC） and cirrhotic liver tissues. This well-documented work shows that VEGF was significantly higher in surrounding cirrhotic liver tissues than in HCC. Authors assessed VEGF expression using immunohistochemistry. The immunohistochemical staining is an efficient tool to assess the percentage of cells stained positively for VEGF but is not really efficient to estimate their true VEGF content. Evaluation of the VEGF protein by an enzyme-linked immunosorbent assay 0ELISA） has been reported, by us and others, to be an efficient tool in order to assess tissue VEGF expression. We have, thus, tested whether the ELISA method might be an efficient tool in order to confirm data reporting higher amounts of VEGF in surrounding cirrhotic liver tissues than in HCC. Deli and colleagues. also correctly pointed out that basic fibroblast growth factor （bFGF） has been reported to act cooperatively on VEGF expression. We have, thus, also assessed bFGF tissue levels in order to search for a putative link between VEGF and bFGF levels in cirrhotic tissues.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Female</subject><subject>Fibroblast Growth Factor 2</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Humans</subject><subject>Immunology</subject><subject>Letters To The Editor</subject><subject>Life Sciences</subject><subject>Liver Cirrhosis</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Neoplasms</subject><subject>Liver Neoplasms - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>病理机制</subject><subject>肝硬化</subject><subject>肝细胞癌</subject><subject>血管内皮生长因子</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2L2zAQxUVp6abbXnssppTCHuyOJMtSLoVl2d0UAr20vQpFHjtKHSkr2Vn631cmYftxkpB-83jzHiFvKVRc1urT466vjpRVTlSKwzOyYIwuS6ZqeE4WFECWS87kBXmV0g6AcS7YS3JBG8EoA7Ugqx-393eF88UWD2YMFodhGkwsrInW-bA3hfFtkaYYw-Rb5_vCuhi3YXS2GNwRYzG6lCZMr8mLzgwJ35zPS_L97vbbzapcf73_cnO9Lm0t1VhaIwRbSkRQdGMw3y1woLU1HAGVBNvWVEmJ3HSqQysRagqyBdNSpA3jl-TzSfcwbfbYWvRjNIM-RLc38ZcOxul_f7zb6j4cdQ1NQ2uRBa5OAtv_xlbXaz2_Qc4JWC2ONLMfTuyj8Z3xvd6FKfq8ns65M4AGBPDZ08ezpxgechaj3rs0R2k8hinpRsrcCFMZrE6gjSGliN2TAQp67nPW1blP7YTOfeaBd39v-wc_F5iB92fFbfD9Qy5Ib4z92bkBNaNccKYY_w3cWagS</recordid><startdate>20060207</startdate><enddate>20060207</enddate><creator>Mathonnet, Muriel</creator><creator>Descottes, Bernard</creator><creator>Valleix, Denis</creator><creator>Labrousse, François</creator><creator>Denizot, Yves</creator><general>Service de Chirurgie Digestive, Endocrinienne et Générale, CHU Dupuytren, Limoges, France%Service de Chirurgie Viscérale et Transplantation, CHU Dupuytren, Limoges, France%Service d'Anatomo-Pathologie, CHU Dupuytren, Limoges, France%UMR CNRS 6101, Faculté de Médecine, Limoges,France</general><general>Baishideng Publishing Group Co. Limited</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>20060207</creationdate><title>VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues</title><author>Mathonnet, Muriel ; Descottes, Bernard ; Valleix, Denis ; Labrousse, François ; Denizot, Yves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-ca55297ee081bae529c03014ca3e0e870cd41877e3af8fec7e04107d0ad1e1623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Female</topic><topic>Fibroblast Growth Factor 2</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Humans</topic><topic>Immunology</topic><topic>Letters To The Editor</topic><topic>Life Sciences</topic><topic>Liver Cirrhosis</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver Neoplasms</topic><topic>Liver Neoplasms - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>病理机制</topic><topic>肝硬化</topic><topic>肝细胞癌</topic><topic>血管内皮生长因子</topic><toplevel>online_resources</toplevel><creatorcontrib>Mathonnet, Muriel</creatorcontrib><creatorcontrib>Descottes, Bernard</creatorcontrib><creatorcontrib>Valleix, Denis</creatorcontrib><creatorcontrib>Labrousse, François</creatorcontrib><creatorcontrib>Denizot, Yves</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mathonnet, Muriel</au><au>Descottes, Bernard</au><au>Valleix, Denis</au><au>Labrousse, François</au><au>Denizot, Yves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2006-02-07</date><risdate>2006</risdate><volume>12</volume><issue>5</issue><spage>830</spage><epage>831</epage><pages>830-831</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>We read with a great interest the recent work of Deli and colleagues. in the World Journal of Gastroenterology reporting vascular endothelial growth factor （VEGF） expression in hepatocellular carcinoma （HCC） and cirrhotic liver tissues. This well-documented work shows that VEGF was significantly higher in surrounding cirrhotic liver tissues than in HCC. Authors assessed VEGF expression using immunohistochemistry. The immunohistochemical staining is an efficient tool to assess the percentage of cells stained positively for VEGF but is not really efficient to estimate their true VEGF content. Evaluation of the VEGF protein by an enzyme-linked immunosorbent assay 0ELISA） has been reported, by us and others, to be an efficient tool in order to assess tissue VEGF expression. We have, thus, tested whether the ELISA method might be an efficient tool in order to confirm data reporting higher amounts of VEGF in surrounding cirrhotic liver tissues than in HCC. Deli and colleagues. also correctly pointed out that basic fibroblast growth factor （bFGF） has been reported to act cooperatively on VEGF expression. We have, thus, also assessed bFGF tissue levels in order to search for a putative link between VEGF and bFGF levels in cirrhotic tissues.</abstract><cop>United States</cop><pub>Service de Chirurgie Digestive, Endocrinienne et Générale, CHU Dupuytren, Limoges, France%Service de Chirurgie Viscérale et Transplantation, CHU Dupuytren, Limoges, France%Service d'Anatomo-Pathologie, CHU Dupuytren, Limoges, France%UMR CNRS 6101, Faculté de Médecine, Limoges,France</pub><pmid>16521208</pmid><doi>10.3748/wjg.v12.i5.830</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2006-02, Vol.12 (5), p.830-831 |
| issn | 1007-9327 2219-2840 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4066145 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Carcinoma, Hepatocellular Carcinoma, Hepatocellular - metabolism Female Fibroblast Growth Factor 2 Fibroblast Growth Factor 2 - metabolism Humans Immunology Letters To The Editor Life Sciences Liver Cirrhosis Liver Cirrhosis - metabolism Liver Neoplasms Liver Neoplasms - metabolism Male Middle Aged Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A - metabolism 病理机制 肝硬化 肝细胞癌 血管内皮生长因子 |
| title | VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T03%3A26%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=VEGF%20in%20hepatocellular%20carcinoma%20and%20surrounding%20cirrhotic%20liver%20tissues&rft.jtitle=World%20journal%20of%20gastroenterology%20:%20WJG&rft.au=Mathonnet,%20Muriel&rft.date=2006-02-07&rft.volume=12&rft.issue=5&rft.spage=830&rft.epage=831&rft.pages=830-831&rft.issn=1007-9327&rft.eissn=2219-2840&rft_id=info:doi/10.3748/wjg.v12.i5.830&rft_dat=%3Cwanfang_jour_pubme%3Ewjg200605032%3C/wanfang_jour_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67728428&rft_id=info:pmid/16521208&rft_cqvip_id=21353282&rft_wanfj_id=wjg200605032&rfr_iscdi=true |