Estimating glutathione synthesis with deuterated water: A model for peptide biosynthesis

Glutathione (GSH), an intracellular tripeptide that combats oxidative stress, must be continually replaced due to loss through conjugation and destruction. Previous methods, estimating the synthesis of GSH in vivo, used constant infusions of labeled amino acid precursors. We developed a new method b...

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Veröffentlicht in:	Analytical biochemistry 2008-08, Vol.379 (1), p.40-44
Hauptverfasser:	Cabral, Carolina B., Bullock, Kevin H., Bischoff, David J., Tompkins, Ronald G., Yu, Yong M., Kelleher, Joanne K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Chromatography, Liquid Deuterated water Deuterium Oxide - chemistry Deuterium Oxide - metabolism Glutathione Glutathione - biosynthesis Glutathione - blood Glutathione - chemistry Isotopomers LC/MS Mass Spectrometry Rabbits
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