Drug Addiction and Stress‐Response Genetic Variability: Association Study in African Americans
Summary Stress is a significant risk factor in the development of drug addictions and in addiction relapse susceptibility. This hypothesis‐driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americ...
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| Veröffentlicht in: | Annals of human genetics 2014-07, Vol.78 (4), p.290-298 |
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| container_title | Annals of human genetics |
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| creator | Levran, Orna Randesi, Matthew Li, Yi Rotrosen, John Ott, Jurg Adelson, Miriam Jeanne Kreek, Mary |
| description | Summary
Stress is a significant risk factor in the development of drug addictions and in addiction relapse susceptibility. This hypothesis‐driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americans. The analysis included 27 genes (124 SNPs) and was performed independently for each addiction. The sample consisted of former heroin addicts in methadone maintenance treatment (n = 314), cocaine addicts (n = 281), and controls (n = 208). Fourteen SNPs showed nominally significant association with heroin addiction (p < 0.05), including the African‐specific, missense SNP rs5376 (Asn334Ser) in the galanin receptor type 1 gene (GALR1) and the functional FKBP5 intronic SNP rs1360780. Thirteen SNPs showed association with cocaine addiction, including the synonymous SNPs rs237902, in the oxytocin receptor gene (OXTR), and rs5374 in GALR1. No signal remained significant after correction for multiple testing. Four additional SNPs (GALR1 rs2717162, AVP rs2282018, CRHBP rs1875999, and NR3C2 rs1040288) were associated with both addictions and may indicate common liability. The study provides preliminary evidence for novel association of variants in several stress‐related genes with heroin and/or cocaine addictions and may enhance the understanding of the interaction between stress and addictions. |
| doi_str_mv | 10.1111/ahg.12064 |
| format | Article |
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Stress is a significant risk factor in the development of drug addictions and in addiction relapse susceptibility. This hypothesis‐driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americans. The analysis included 27 genes (124 SNPs) and was performed independently for each addiction. The sample consisted of former heroin addicts in methadone maintenance treatment (n = 314), cocaine addicts (n = 281), and controls (n = 208). Fourteen SNPs showed nominally significant association with heroin addiction (p < 0.05), including the African‐specific, missense SNP rs5376 (Asn334Ser) in the galanin receptor type 1 gene (GALR1) and the functional FKBP5 intronic SNP rs1360780. Thirteen SNPs showed association with cocaine addiction, including the synonymous SNPs rs237902, in the oxytocin receptor gene (OXTR), and rs5374 in GALR1. No signal remained significant after correction for multiple testing. Four additional SNPs (GALR1 rs2717162, AVP rs2282018, CRHBP rs1875999, and NR3C2 rs1040288) were associated with both addictions and may indicate common liability. The study provides preliminary evidence for novel association of variants in several stress‐related genes with heroin and/or cocaine addictions and may enhance the understanding of the interaction between stress and addictions.</description><identifier>ISSN: 0003-4800</identifier><identifier>EISSN: 1469-1809</identifier><identifier>DOI: 10.1111/ahg.12064</identifier><identifier>PMID: 24766650</identifier><identifier>CODEN: ANHGAA</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>African Americans ; African Americans - genetics ; AVP ; Case-Control Studies ; cocaine addiction ; Computational Biology ; Drug addiction ; Female ; FKBP5 ; GALR1 ; Genetic Association Studies ; Genetic Predisposition to Disease ; Heroin ; Heroin addiction ; HPA axis ; Humans ; Male ; Methadone ; NR3C2 ; OXTR ; Polymorphism, Single Nucleotide ; stress ; Stress, Physiological - genetics ; Stress, Psychological - genetics ; Substance abuse treatment ; Substance-Related Disorders - etiology</subject><ispartof>Annals of human genetics, 2014-07, Vol.78 (4), p.290-298</ispartof><rights>2014 John Wiley & Sons Ltd/University College London</rights><rights>2014 John Wiley & Sons Ltd/University College London.</rights><rights>Copyright © 2014 John Wiley & Sons Ltd/University College London</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5084-544040bef6894fcd7f6623491123e5f1d5aa6a2371ff6461c6efc0fbfa8048393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fahg.12064$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fahg.12064$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24766650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levran, Orna</creatorcontrib><creatorcontrib>Randesi, Matthew</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Rotrosen, John</creatorcontrib><creatorcontrib>Ott, Jurg</creatorcontrib><creatorcontrib>Adelson, Miriam</creatorcontrib><creatorcontrib>Jeanne Kreek, Mary</creatorcontrib><title>Drug Addiction and Stress‐Response Genetic Variability: Association Study in African Americans</title><title>Annals of human genetics</title><addtitle>Ann Hum Genet</addtitle><description>Summary
Stress is a significant risk factor in the development of drug addictions and in addiction relapse susceptibility. This hypothesis‐driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americans. The analysis included 27 genes (124 SNPs) and was performed independently for each addiction. The sample consisted of former heroin addicts in methadone maintenance treatment (n = 314), cocaine addicts (n = 281), and controls (n = 208). Fourteen SNPs showed nominally significant association with heroin addiction (p < 0.05), including the African‐specific, missense SNP rs5376 (Asn334Ser) in the galanin receptor type 1 gene (GALR1) and the functional FKBP5 intronic SNP rs1360780. Thirteen SNPs showed association with cocaine addiction, including the synonymous SNPs rs237902, in the oxytocin receptor gene (OXTR), and rs5374 in GALR1. No signal remained significant after correction for multiple testing. Four additional SNPs (GALR1 rs2717162, AVP rs2282018, CRHBP rs1875999, and NR3C2 rs1040288) were associated with both addictions and may indicate common liability. The study provides preliminary evidence for novel association of variants in several stress‐related genes with heroin and/or cocaine addictions and may enhance the understanding of the interaction between stress and addictions.</description><subject>African Americans</subject><subject>African Americans - genetics</subject><subject>AVP</subject><subject>Case-Control Studies</subject><subject>cocaine addiction</subject><subject>Computational Biology</subject><subject>Drug addiction</subject><subject>Female</subject><subject>FKBP5</subject><subject>GALR1</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Heroin</subject><subject>Heroin addiction</subject><subject>HPA axis</subject><subject>Humans</subject><subject>Male</subject><subject>Methadone</subject><subject>NR3C2</subject><subject>OXTR</subject><subject>Polymorphism, Single Nucleotide</subject><subject>stress</subject><subject>Stress, Physiological - genetics</subject><subject>Stress, Psychological - genetics</subject><subject>Substance abuse treatment</subject><subject>Substance-Related Disorders - etiology</subject><issn>0003-4800</issn><issn>1469-1809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctOwzAQRS0EouWx4AdQJDZsQsex4yQskCIeLRISEq-tcR27NUqdYieg7vgEvpEvwZSHAG9mpDm-vp6L0A6GAxzOQEwnBzgBRldQH1NWxDiHYhX1AYDENAfooQ3vHwBwklOyjnoJzRhjKfTR_YnrJlFZVUa2prGRsFV03Trl_dvL65Xy88Z6FQ2VVa2R0Z1wRoxNbdrFYVR630gjlteu265aRMZGpXZGilBnatn4LbSmRe3V9lfdRLdnpzfHo_jicnh-XF7EMoWcximlQGGsNMsLqmWVacYSQguME6JSjatUCCYSkmGtGWVYMqUl6LEWOdCcFGQTHX3qzrvxTFVS2daJms-dmQm34I0w_O_EmimfNE-cAksTzILA_peAax475Vs-M16quhZWNZ3n-MNieIvigO79Qx-aztnwvUARxrIsbDpQu78d_Vj5Xn4ABp_As6nV4meOgX-kykOqfJkqL0fDZUPeAVA4lUs</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Levran, Orna</creator><creator>Randesi, Matthew</creator><creator>Li, Yi</creator><creator>Rotrosen, John</creator><creator>Ott, Jurg</creator><creator>Adelson, Miriam</creator><creator>Jeanne Kreek, Mary</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>201407</creationdate><title>Drug Addiction and Stress‐Response Genetic Variability: Association Study in African Americans</title><author>Levran, Orna ; Randesi, Matthew ; Li, Yi ; Rotrosen, John ; Ott, Jurg ; Adelson, Miriam ; Jeanne Kreek, Mary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5084-544040bef6894fcd7f6623491123e5f1d5aa6a2371ff6461c6efc0fbfa8048393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>African Americans</topic><topic>African Americans - genetics</topic><topic>AVP</topic><topic>Case-Control Studies</topic><topic>cocaine addiction</topic><topic>Computational Biology</topic><topic>Drug addiction</topic><topic>Female</topic><topic>FKBP5</topic><topic>GALR1</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Heroin</topic><topic>Heroin addiction</topic><topic>HPA axis</topic><topic>Humans</topic><topic>Male</topic><topic>Methadone</topic><topic>NR3C2</topic><topic>OXTR</topic><topic>Polymorphism, Single Nucleotide</topic><topic>stress</topic><topic>Stress, Physiological - genetics</topic><topic>Stress, Psychological - genetics</topic><topic>Substance abuse treatment</topic><topic>Substance-Related Disorders - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levran, Orna</creatorcontrib><creatorcontrib>Randesi, Matthew</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Rotrosen, John</creatorcontrib><creatorcontrib>Ott, Jurg</creatorcontrib><creatorcontrib>Adelson, Miriam</creatorcontrib><creatorcontrib>Jeanne Kreek, Mary</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levran, Orna</au><au>Randesi, Matthew</au><au>Li, Yi</au><au>Rotrosen, John</au><au>Ott, Jurg</au><au>Adelson, Miriam</au><au>Jeanne Kreek, Mary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug Addiction and Stress‐Response Genetic Variability: Association Study in African Americans</atitle><jtitle>Annals of human genetics</jtitle><addtitle>Ann Hum Genet</addtitle><date>2014-07</date><risdate>2014</risdate><volume>78</volume><issue>4</issue><spage>290</spage><epage>298</epage><pages>290-298</pages><issn>0003-4800</issn><eissn>1469-1809</eissn><coden>ANHGAA</coden><abstract>Summary
Stress is a significant risk factor in the development of drug addictions and in addiction relapse susceptibility. This hypothesis‐driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americans. The analysis included 27 genes (124 SNPs) and was performed independently for each addiction. The sample consisted of former heroin addicts in methadone maintenance treatment (n = 314), cocaine addicts (n = 281), and controls (n = 208). Fourteen SNPs showed nominally significant association with heroin addiction (p < 0.05), including the African‐specific, missense SNP rs5376 (Asn334Ser) in the galanin receptor type 1 gene (GALR1) and the functional FKBP5 intronic SNP rs1360780. Thirteen SNPs showed association with cocaine addiction, including the synonymous SNPs rs237902, in the oxytocin receptor gene (OXTR), and rs5374 in GALR1. No signal remained significant after correction for multiple testing. Four additional SNPs (GALR1 rs2717162, AVP rs2282018, CRHBP rs1875999, and NR3C2 rs1040288) were associated with both addictions and may indicate common liability. The study provides preliminary evidence for novel association of variants in several stress‐related genes with heroin and/or cocaine addictions and may enhance the understanding of the interaction between stress and addictions.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24766650</pmid><doi>10.1111/ahg.12064</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | African Americans African Americans - genetics AVP Case-Control Studies cocaine addiction Computational Biology Drug addiction Female FKBP5 GALR1 Genetic Association Studies Genetic Predisposition to Disease Heroin Heroin addiction HPA axis Humans Male Methadone NR3C2 OXTR Polymorphism, Single Nucleotide stress Stress, Physiological - genetics Stress, Psychological - genetics Substance abuse treatment Substance-Related Disorders - etiology |
| title | Drug Addiction and Stress‐Response Genetic Variability: Association Study in African Americans |
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