The localization of histone H3K27me3 demethylase Jmjd3 is dynamically regulated

Jmjd3 is required for cellular differentiation and senescence, and inhibits the induction of pluripotent stem cells by demethylating histone 3 lysine 27 trimethylation (H3K27me3). Although recent studies reveal crucial biological roles for Jmjd3, it is unclear how its demethylase activity is control...

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Veröffentlicht in:	Epigenetics 2014-06, Vol.9 (6), p.834-841
Hauptverfasser:	Kamikawa, Yasunao F, Donohoe, Mary E
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Brief Report Catalytic Domain Cell Nucleus - metabolism Cells, Cultured Fatty Acids, Unsaturated - pharmacology Histones - metabolism Humans Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Karyopherins - metabolism Lysine - metabolism Methylation Mice Nuclear Localization Signals - metabolism
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