Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)

Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of vascular development, the molecular mechanisms underlying Ang-1 function are almost completely uncharacterized. In this report, we demonstrate that Ang-1, via Akt activation, is a potent inhibitor of the forkhe...

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Veröffentlicht in:	Genes & development 2004-05, Vol.18 (9), p.1060-1071
Hauptverfasser:	Daly, Christopher, Wong, Vivian, Burova, Elena, Wei, Yi, Zabski, Stephanie, Griffiths, Jennifer, Lai, Ka-Man, Lin, Hsin Chieh, Ioffe, Ella, Yancopoulos, George D, Rudge, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-1 - pharmacology Angiopoietin-1 - physiology Animals Apoptosis - drug effects Base Sequence Cattle Cells, Cultured DNA, Complementary - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Forkhead Box Protein O1 Forkhead Transcription Factors Gene Expression - drug effects Gene Expression Profiling Humans Models, Biological Oligonucleotide Array Sequence Analysis Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-akt Recombinant Proteins - pharmacology Research Papers Signal Transduction Transcription Factors - genetics Transcription Factors - physiology
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