Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice

Astrocytes limit inflammation after CNS injury, at least partially by physically containing it within an astrocytic scar at the injury border. We report here that astrocytic transforming growth factor‐beta (TGFβ) signaling is a second, distinct mechanism that astrocytes utilize to limit neuroinflamm...

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Veröffentlicht in:	Glia 2014-08, Vol.62 (8), p.1227-1240
Hauptverfasser:	Cekanaviciute, Egle, Fathali, Nancy, Doyle, Kristian P., Williams, Aaron M., Han, Jullet, Buckwalter, Marion S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocytes Astrocytes - immunology Astrocytes - pathology Beta CD11b Antigen - metabolism Cerebral Cortex - immunology Cerebral Cortex - pathology cytokines Disease Models, Animal Female immunity Infarction, Middle Cerebral Artery - immunology Infarction, Middle Cerebral Artery - pathology inflammation ischemia Macrophages - pathology Macrophages - physiology Medical research Mice, Transgenic Microglia - immunology Microglia - pathology Monocytes - pathology Monocytes - physiology Motor Activity - physiology Neuroimmunomodulation - physiology Signal Transduction Stroke - immunology Stroke - pathology Thrombospondin 1 - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1 - metabolism
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