Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs

Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive tumor type that is resistant to chemotherapy and there are no effective therapies. MPNSTs have been shown to have gene amplification for receptor tyrosine kinases (RTK), PDGFR and c-Kit. We tested the c-Kit inhibitor, imatinib, a...

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Veröffentlicht in:	Clinical cancer research 2014-06, Vol.20 (12), p.3146-3158
Hauptverfasser:	PATWARDHAN, Parag P, SURRIGA, Oliver, BECKMAN, Michael J, DE STANCHINA, Elisa, DEMATTEO, Ronald P, TAP, William D, SCHWARTZ, Gary K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Benzamides - administration & dosage Biological and medical sciences Blotting, Western Cell Proliferation - drug effects Humans Imatinib Mesylate Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Medical sciences Mice Mice, Inbred ICR Mice, SCID Neurilemmoma - drug therapy Neurilemmoma - metabolism Neurilemmoma - pathology Pharmacology. Drug treatments Piperazines - administration & dosage Proto-Oncogene Proteins c-kit - antagonists & inhibitors Pyrimidines - administration & dosage Pyrroles - pharmacology Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors Sirolimus - administration & dosage Tumor Cells, Cultured Xenograft Model Antitumor Assays
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