Interferon-β suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway

The induction of an antiviral state by type I interferons (IFN) was evaluated in primary trigeminal ganglion cell cultures using herpes simplex virus type 1 (HSV-1). Cells treated with mouse IFN-β consistently showed the greatest resistance to HSV-1 infection in comparison to cells treated with IFN-...

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Veröffentlicht in:	Journal of neuroimmunology 2003-08, Vol.141 (1), p.40-46
Hauptverfasser:	Carr, Daniel J.J., Al-khatib, Khaldun, James, Cassandra M., Silverman, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - deficiency Antiviral Agents - genetics Antiviral Agents - physiology Cell Line Cells, Cultured Cercopithecus aethiops Endoribonucleases - deficiency Endoribonucleases - genetics Endoribonucleases - physiology Female Gene Expression Regulation, Viral - immunology Herpes simplex virus Herpes simplex virus 1 Herpesvirus 1, Human - genetics Herpesvirus 1, Human - immunology HSV-1 IFN-α IFN-β Immunity, Innate - genetics Immunophenotyping Interferon-beta - physiology Mice Mice, Inbred C57BL Mice, Inbred ICR Neuroimmunology OAS PKR Signal Transduction - genetics Signal Transduction - immunology Transfection Trigeminal Ganglion - cytology Trigeminal Ganglion - enzymology Trigeminal Ganglion - immunology Trigeminal Ganglion - virology Vero Cells Virus Replication - genetics Virus Replication - immunology
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