Effects of interleukin-33 on cardiac fibroblast gene expression and activity

► IL-33/ST2 signaling was recently reported to have cardiac protective roles. ► We detected ST2 expression on rat cardiac fibroblasts. ► We investigated the regulatory roles of IL-33 on rat cardiac fibroblasts. ► IL-33 induced cell inflammatory cytokine but not the collagen production. ► MAPK and NF...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2012-06, Vol.58 (3), p.368-379
Hauptverfasser:	Zhu, Jinyu, Carver, Wayne
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Animals Autoimmune diseases Base Sequence Blotting, Western c-Jun amino-terminal kinase Cardiac fibroblast Cardiovascular diseases CD4-positive T-lymphocytes Cell activation Cell migration cell movement Cells, Cultured Chemokines Collagen Collagen (type I) Collagen (type III) DNA Primers Enzyme-Linked Immunosorbent Assay Extracellular matrix Extracellular signal-regulated kinase Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis gels Gene expression Gene Expression - drug effects genes Heart Heart - drug effects Hemorrhage Inflammation Interleukin 1 Interleukin 6 Interleukin-33 Interleukins - pharmacology Leukocyte migration Lymphocytes B Male MAP kinase mechanical loads Mechanical properties mice migratory behavior mitogen-activated protein kinase Monocyte chemoattractant protein 1 Myocardium - cytology Myocardium - metabolism NF- Kappa B protein protective effect Rats Rats, Sprague-Dawley Receptors, Interleukin - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal transduction Signal Transduction - drug effects Stress transcription factor NF-kappa B
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