MicroRNA-mRNA functional pairs for cisplatin resistance in ovarian cancer cells
Ovarian cancer is the leading cause of death in women worldwide. Cisplatin is the core of first-line chemotherapy for patients with advanced ovarian cancer. Many patients eventually become resistant to cisplatin, diminishing its therapeutic effect. MicroRNAs （miRNAs） have critical functions in diver...
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| Veröffentlicht in: | Ai zheng 2014-06, Vol.33 (6), p.285-294 |
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| description | Ovarian cancer is the leading cause of death in women worldwide. Cisplatin is the core of first-line chemotherapy for patients with advanced ovarian cancer. Many patients eventually become resistant to cisplatin, diminishing its therapeutic effect. MicroRNAs （miRNAs） have critical functions in diverse biological processes. Using miRNA profiling and polymerase chain reaction validation, we identified a panel of differentially expressed miRNAs and their potential targets in cisplatin-resistant SKOV3/DDP ovarian cancer cells relative to cisplatin-sensitive SKOV3 parental cells. More specifically, our results revealed significant changes in the expression of 13 of 663 miRNAs analyzed, including 11 that were up-regulated and 2 that were down-regulated in SKOV3/DDP cells with or without cisplatin treatment compared with SKOV3 cells with or without cisplatin treatment. miRNA array and mRNA array data were further analyzed using Ingenuity Pathway Analysis software. Bioinformatics analysis suggests that the genes ANKRD17, SMC1A, SUMO1, GTF2H1, and TP73, which are involved in DNA damage signaling pathways, are potential targets of miRNAs in promoting cisplatin resistance. This study highlights candidate miRNA-mRNA interactions that may contribute to cisplatin resistance in ovarian cancer. |
| doi_str_mv | 10.5732/cjc.013.10136 |
| format | Article |
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Cisplatin is the core of first-line chemotherapy for patients with advanced ovarian cancer. Many patients eventually become resistant to cisplatin, diminishing its therapeutic effect. MicroRNAs （miRNAs） have critical functions in diverse biological processes. Using miRNA profiling and polymerase chain reaction validation, we identified a panel of differentially expressed miRNAs and their potential targets in cisplatin-resistant SKOV3/DDP ovarian cancer cells relative to cisplatin-sensitive SKOV3 parental cells. More specifically, our results revealed significant changes in the expression of 13 of 663 miRNAs analyzed, including 11 that were up-regulated and 2 that were down-regulated in SKOV3/DDP cells with or without cisplatin treatment compared with SKOV3 cells with or without cisplatin treatment. miRNA array and mRNA array data were further analyzed using Ingenuity Pathway Analysis software. Bioinformatics analysis suggests that the genes ANKRD17, SMC1A, SUMO1, GTF2H1, and TP73, which are involved in DNA damage signaling pathways, are potential targets of miRNAs in promoting cisplatin resistance. This study highlights candidate miRNA-mRNA interactions that may contribute to cisplatin resistance in ovarian cancer.</description><identifier>ISSN: 1000-467X</identifier><identifier>EISSN: 1944-446X</identifier><identifier>DOI: 10.5732/cjc.013.10136</identifier><identifier>PMID: 24589211</identifier><language>eng</language><publisher>England: Laboratory of Cel and Molecular Biology & State Key Laboratory of Molecular 0ncology, Cancer Institute&Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical college, Beijing 100021, P. R. China%Department of 0bstetrics and Gynecology, China Meitan General Hospital, Beijing 100021, P. R. China</publisher><subject>Cell Cycle Proteins ; Cell Line, Tumor ; Chromosomal Proteins, Non-Histone ; Cisplatin ; Cysteine Endopeptidases ; DNA-Binding Proteins ; Down-Regulation ; Drug Resistance, Neoplasm ; Endopeptidases ; Female ; Humans ; MicroRNAs ; miRNA ; Nuclear Proteins ; Original ; Ovarian Neoplasms ; Phosphoproteins ; RNA, Messenger ; RNA基因 ; Signal Transduction ; Transcription Factors, TFII ; Tumor Protein p73 ; Tumor Suppressor Proteins ; Up-Regulation ; 信号传导途径 ; 卵巢癌细胞 ; 治疗效果 ; 耐药性 ; 聚合酶链反应 ; 顺铂</subject><ispartof>Ai zheng, 2014-06, Vol.33 (6), p.285-294</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Chinese Journal of Cancer 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-45543daab8f55ed59d21a579e9b4a495a077cb50fa7864f7c5274884dea0bd5f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/90720X/90720X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059866/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059866/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24589211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Mei</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Hu, Chen-Fei</creatorcontrib><creatorcontrib>Xu, Qing</creatorcontrib><creatorcontrib>Zhu, Hong-Xia</creatorcontrib><creatorcontrib>Xu, Ning-Zhi</creatorcontrib><title>MicroRNA-mRNA functional pairs for cisplatin resistance in ovarian cancer cells</title><title>Ai zheng</title><addtitle>Chinese Journal of Cancer</addtitle><description>Ovarian cancer is the leading cause of death in women worldwide. Cisplatin is the core of first-line chemotherapy for patients with advanced ovarian cancer. Many patients eventually become resistant to cisplatin, diminishing its therapeutic effect. MicroRNAs （miRNAs） have critical functions in diverse biological processes. Using miRNA profiling and polymerase chain reaction validation, we identified a panel of differentially expressed miRNAs and their potential targets in cisplatin-resistant SKOV3/DDP ovarian cancer cells relative to cisplatin-sensitive SKOV3 parental cells. More specifically, our results revealed significant changes in the expression of 13 of 663 miRNAs analyzed, including 11 that were up-regulated and 2 that were down-regulated in SKOV3/DDP cells with or without cisplatin treatment compared with SKOV3 cells with or without cisplatin treatment. miRNA array and mRNA array data were further analyzed using Ingenuity Pathway Analysis software. Bioinformatics analysis suggests that the genes ANKRD17, SMC1A, SUMO1, GTF2H1, and TP73, which are involved in DNA damage signaling pathways, are potential targets of miRNAs in promoting cisplatin resistance. This study highlights candidate miRNA-mRNA interactions that may contribute to cisplatin resistance in ovarian cancer.</description><subject>Cell Cycle Proteins</subject><subject>Cell Line, Tumor</subject><subject>Chromosomal Proteins, Non-Histone</subject><subject>Cisplatin</subject><subject>Cysteine Endopeptidases</subject><subject>DNA-Binding Proteins</subject><subject>Down-Regulation</subject><subject>Drug Resistance, Neoplasm</subject><subject>Endopeptidases</subject><subject>Female</subject><subject>Humans</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Nuclear Proteins</subject><subject>Original</subject><subject>Ovarian Neoplasms</subject><subject>Phosphoproteins</subject><subject>RNA, Messenger</subject><subject>RNA基因</subject><subject>Signal Transduction</subject><subject>Transcription Factors, TFII</subject><subject>Tumor Protein p73</subject><subject>Tumor Suppressor Proteins</subject><subject>Up-Regulation</subject><subject>信号传导途径</subject><subject>卵巢癌细胞</subject><subject>治疗效果</subject><subject>耐药性</subject><subject>聚合酶链反应</subject><subject>顺铂</subject><issn>1000-467X</issn><issn>1944-446X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtPxCAQh4nR-D56NTWeuw4tlHIxMRtfiY_EaOKNTCmsbLp0ha5G_3rRVaOXgYEvv4GPkD0KIy7K4khP9QhoOaKpVCtkk0rGcsaqx9W0B4CcVeJxg2zFOAVgVIp6nWwUjNeyoHST3F47Hfq7m5N8lkpmF14PrvfYZXN0IWa2D5l2cd7h4HwWTHRxQK9Nlrr-BYNDn-nPg4SZros7ZM1iF83u97pNHs5O78cX-dXt-eX45CrXHMSQM85Z2SI2teXctFy2BUUupJENQyY5ghC64WBR1BWzQvNCsLpmrUFoWm7LbXK8zJ0vmplptfFDwE7Ng5theFM9OvX_xrsnNelfFAMu66pKAYfLgFf0Fv1ETftFSP-OyrwXQBlUAGWi8iWVJMUYjP2dQEF9-lfJv0rq1Zf_xO__fdYv_SM8AQffgU-9nzy7NPiH4VCUkvKy_AAVeY1E</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Liu, Mei</creator><creator>Zhang, Xin</creator><creator>Hu, Chen-Fei</creator><creator>Xu, Qing</creator><creator>Zhu, Hong-Xia</creator><creator>Xu, Ning-Zhi</creator><general>Laboratory of Cel and Molecular Biology & State Key Laboratory of Molecular 0ncology, Cancer Institute&Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical college, Beijing 100021, P. 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Cisplatin is the core of first-line chemotherapy for patients with advanced ovarian cancer. Many patients eventually become resistant to cisplatin, diminishing its therapeutic effect. MicroRNAs （miRNAs） have critical functions in diverse biological processes. Using miRNA profiling and polymerase chain reaction validation, we identified a panel of differentially expressed miRNAs and their potential targets in cisplatin-resistant SKOV3/DDP ovarian cancer cells relative to cisplatin-sensitive SKOV3 parental cells. More specifically, our results revealed significant changes in the expression of 13 of 663 miRNAs analyzed, including 11 that were up-regulated and 2 that were down-regulated in SKOV3/DDP cells with or without cisplatin treatment compared with SKOV3 cells with or without cisplatin treatment. miRNA array and mRNA array data were further analyzed using Ingenuity Pathway Analysis software. Bioinformatics analysis suggests that the genes ANKRD17, SMC1A, SUMO1, GTF2H1, and TP73, which are involved in DNA damage signaling pathways, are potential targets of miRNAs in promoting cisplatin resistance. This study highlights candidate miRNA-mRNA interactions that may contribute to cisplatin resistance in ovarian cancer.</abstract><cop>England</cop><pub>Laboratory of Cel and Molecular Biology & State Key Laboratory of Molecular 0ncology, Cancer Institute&Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical college, Beijing 100021, P. R. China%Department of 0bstetrics and Gynecology, China Meitan General Hospital, Beijing 100021, P. R. China</pub><pmid>24589211</pmid><doi>10.5732/cjc.013.10136</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Ai zheng, 2014-06, Vol.33 (6), p.285-294 |
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| subjects | Cell Cycle Proteins Cell Line, Tumor Chromosomal Proteins, Non-Histone Cisplatin Cysteine Endopeptidases DNA-Binding Proteins Down-Regulation Drug Resistance, Neoplasm Endopeptidases Female Humans MicroRNAs miRNA Nuclear Proteins Original Ovarian Neoplasms Phosphoproteins RNA, Messenger RNA基因 Signal Transduction Transcription Factors, TFII Tumor Protein p73 Tumor Suppressor Proteins Up-Regulation 信号传导途径 卵巢癌细胞 治疗效果 耐药性 聚合酶链反应 顺铂 |
| title | MicroRNA-mRNA functional pairs for cisplatin resistance in ovarian cancer cells |
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