Retinoblastoma and ambient exposure to air toxics in the perinatal period
We examined ambient exposure to specific air toxics in the perinatal period in relation to retinoblastoma development. Cases were ascertained from California Cancer Registry records of children diagnosed between 1990 and 2007 and matched to California birth certificates. Controls were randomly selec...
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| Veröffentlicht in: | Journal of exposure science & environmental epidemiology 2015-03, Vol.25 (2), p.182-186 |
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| creator | Heck, Julia E Park, Andrew S Qiu, Jiaheng Cockburn, Myles Ritz, Beate |
| description | We examined ambient exposure to specific air toxics in the perinatal period in relation to retinoblastoma development. Cases were ascertained from California Cancer Registry records of children diagnosed between 1990 and 2007 and matched to California birth certificates. Controls were randomly selected from state birth records for the same time period. We chose 27 air toxics for the present study that had been listed as possible, probable, or established human carcinogens by the International Agency for Research on Cancer. Children (103 cases and 30,601 controls) included in the study lived within 5 miles of an air pollution monitor. Using logistic regression analyses, we modeled the risk of retinoblastoma due to air toxic exposure, separately for exposures in pregnancy and the first year of life. With a per interquartile range increase in air toxic exposure, retinoblastoma risk was found to be increased with pregnancy exposure to benzene (OR=1.67, 95% CI: 1.06, 2.64) and other toxics which primarily arise from gasoline and diesel combustion: toluene, 1,3-butadiene, ethyl benzene, ortho-xylene, and meta/para-xylene; these six toxics were highly correlated. Retinoblastoma risk was also increased with pregnancy exposure to chloroform (OR=1.35, 95% CI: 1.07, 1.70), chromium (OR=1.29, 95% CI: 1.04, 1.60), para-dichlorobenzene (OR=1.24, 95% CI: 1.04, 1.49), nickel (OR=1.48, 95% CI: 1.08, 2.01), and in the first year of life, acetaldehyde (OR=1.62, 95% CI: 1.06, 2.48). Sources of these agents are discussed. |
| doi_str_mv | 10.1038/jes.2013.84 |
| format | Article |
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Cases were ascertained from California Cancer Registry records of children diagnosed between 1990 and 2007 and matched to California birth certificates. Controls were randomly selected from state birth records for the same time period. We chose 27 air toxics for the present study that had been listed as possible, probable, or established human carcinogens by the International Agency for Research on Cancer. Children (103 cases and 30,601 controls) included in the study lived within 5 miles of an air pollution monitor. Using logistic regression analyses, we modeled the risk of retinoblastoma due to air toxic exposure, separately for exposures in pregnancy and the first year of life. With a per interquartile range increase in air toxic exposure, retinoblastoma risk was found to be increased with pregnancy exposure to benzene (OR=1.67, 95% CI: 1.06, 2.64) and other toxics which primarily arise from gasoline and diesel combustion: toluene, 1,3-butadiene, ethyl benzene, ortho-xylene, and meta/para-xylene; these six toxics were highly correlated. Retinoblastoma risk was also increased with pregnancy exposure to chloroform (OR=1.35, 95% CI: 1.07, 1.70), chromium (OR=1.29, 95% CI: 1.04, 1.60), para-dichlorobenzene (OR=1.24, 95% CI: 1.04, 1.49), nickel (OR=1.48, 95% CI: 1.08, 2.01), and in the first year of life, acetaldehyde (OR=1.62, 95% CI: 1.06, 2.48). Sources of these agents are discussed.</description><identifier>ISSN: 1559-0631</identifier><identifier>EISSN: 1559-064X</identifier><identifier>DOI: 10.1038/jes.2013.84</identifier><identifier>PMID: 24280682</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>1,3-Butadiene ; 692/499 ; 692/699/67/1484 ; 704/172 ; Acetaldehyde ; Adult ; Air Pollutants - adverse effects ; Air pollution ; Analysis ; Benzene ; Birth ; Butadiene ; California - epidemiology ; Cancer ; Cancer in children ; Carcinogens ; Carcinogens, Environmental - adverse effects ; Carcinogens, Environmental - analysis ; Case-Control Studies ; Chemical industry ; Child, Preschool ; Children ; Chloroform ; Chromium ; Dichlorobenzene ; Environmental aspects ; Environmental Monitoring ; Epidemiology ; Ethyl benzene ; Exposure ; Female ; Gasoline ; Gasoline - adverse effects ; Gasoline - analysis ; Health aspects ; Health risk assessment ; Humans ; Hydrocarbons ; Infant ; Logistic Models ; Male ; Maternal Exposure - adverse effects ; Medicine ; Medicine & Public Health ; Nickel ; original-article ; p-Xylene ; Pediatric research ; Perinatal Care ; Perinatal exposure ; Pollution monitoring ; Pregnancy ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - epidemiology ; Registries ; Regression analysis ; Retina ; Retinoblastoma ; Retinoblastoma - chemically induced ; Retinoblastoma - epidemiology ; Risk ; Risk factors ; Toluene ; Tumors ; Xylene</subject><ispartof>Journal of exposure science & environmental epidemiology, 2015-03, Vol.25 (2), p.182-186</ispartof><rights>Nature America, Inc. 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2015</rights><rights>Nature America, Inc. 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-60d48e7da12beb73e34743522b739b321f30e638473456ae35a7634998e610f03</citedby><cites>FETCH-LOGICAL-c669t-60d48e7da12beb73e34743522b739b321f30e638473456ae35a7634998e610f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jes.2013.84$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jes.2013.84$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24280682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heck, Julia E</creatorcontrib><creatorcontrib>Park, Andrew S</creatorcontrib><creatorcontrib>Qiu, Jiaheng</creatorcontrib><creatorcontrib>Cockburn, Myles</creatorcontrib><creatorcontrib>Ritz, Beate</creatorcontrib><title>Retinoblastoma and ambient exposure to air toxics in the perinatal period</title><title>Journal of exposure science & environmental epidemiology</title><addtitle>J Expo Sci Environ Epidemiol</addtitle><addtitle>J Expo Sci Environ Epidemiol</addtitle><description>We examined ambient exposure to specific air toxics in the perinatal period in relation to retinoblastoma development. Cases were ascertained from California Cancer Registry records of children diagnosed between 1990 and 2007 and matched to California birth certificates. Controls were randomly selected from state birth records for the same time period. We chose 27 air toxics for the present study that had been listed as possible, probable, or established human carcinogens by the International Agency for Research on Cancer. Children (103 cases and 30,601 controls) included in the study lived within 5 miles of an air pollution monitor. Using logistic regression analyses, we modeled the risk of retinoblastoma due to air toxic exposure, separately for exposures in pregnancy and the first year of life. With a per interquartile range increase in air toxic exposure, retinoblastoma risk was found to be increased with pregnancy exposure to benzene (OR=1.67, 95% CI: 1.06, 2.64) and other toxics which primarily arise from gasoline and diesel combustion: toluene, 1,3-butadiene, ethyl benzene, ortho-xylene, and meta/para-xylene; these six toxics were highly correlated. Retinoblastoma risk was also increased with pregnancy exposure to chloroform (OR=1.35, 95% CI: 1.07, 1.70), chromium (OR=1.29, 95% CI: 1.04, 1.60), para-dichlorobenzene (OR=1.24, 95% CI: 1.04, 1.49), nickel (OR=1.48, 95% CI: 1.08, 2.01), and in the first year of life, acetaldehyde (OR=1.62, 95% CI: 1.06, 2.48). Sources of these agents are discussed.</description><subject>1,3-Butadiene</subject><subject>692/499</subject><subject>692/699/67/1484</subject><subject>704/172</subject><subject>Acetaldehyde</subject><subject>Adult</subject><subject>Air Pollutants - adverse effects</subject><subject>Air pollution</subject><subject>Analysis</subject><subject>Benzene</subject><subject>Birth</subject><subject>Butadiene</subject><subject>California - epidemiology</subject><subject>Cancer</subject><subject>Cancer in children</subject><subject>Carcinogens</subject><subject>Carcinogens, Environmental - adverse effects</subject><subject>Carcinogens, Environmental - analysis</subject><subject>Case-Control Studies</subject><subject>Chemical industry</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chloroform</subject><subject>Chromium</subject><subject>Dichlorobenzene</subject><subject>Environmental aspects</subject><subject>Environmental Monitoring</subject><subject>Epidemiology</subject><subject>Ethyl benzene</subject><subject>Exposure</subject><subject>Female</subject><subject>Gasoline</subject><subject>Gasoline - adverse effects</subject><subject>Gasoline - analysis</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hydrocarbons</subject><subject>Infant</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Maternal Exposure - adverse effects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nickel</subject><subject>original-article</subject><subject>p-Xylene</subject><subject>Pediatric research</subject><subject>Perinatal Care</subject><subject>Perinatal exposure</subject><subject>Pollution monitoring</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Registries</subject><subject>Regression analysis</subject><subject>Retina</subject><subject>Retinoblastoma</subject><subject>Retinoblastoma - chemically induced</subject><subject>Retinoblastoma - epidemiology</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Toluene</subject><subject>Tumors</subject><subject>Xylene</subject><issn>1559-0631</issn><issn>1559-064X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkttrFDEUxgex2Fp98l0GBBF019wvL8JSvBQKgij4FjIzZ3azzCRrkintf2-2W9dtKUoeziHnly8nX05VvcBojhFV79eQ5gRhOlfsUXWCOdczJNjPx_uc4uPqaUprhBiTAj2pjgkjCglFTqrzb5CdD81gUw6jra3vajs2Dnyu4WoT0hShzqG2LpZw5dpUO1_nFdQbiM7bbIebLHTPqqPeDgme38bT6senj9_Pvswuvn4-P1tczFohdJ4J1DEFsrOYNNBICpRJRjkhJdcNJbinCARVTFLGhQXKrRSUaa1AYNQjelp92OlupmaEri2dRjuYTXSjjdcmWGfuVrxbmWW4NAxxLRUrAm9uBWL4NUHKZnSphWGwHsKUDBaCESQZUgV9dQ9dhyn68jxDKMUCa8LlvygsOOdYIUr-Uks7gHG-D6W7dnu1WTBUxISUvFDzB6iyOhhdGzz0ruzfOfD64MAK7JBXKQxTdsEnsyieYa2RxP8DDxXf7sA2hpQi9HtvMTLbiTNl4sx24syNmy8Pv2PP_hmxArzbAamU_BLigTsP6P0Go5zbJg</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Heck, 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and ambient exposure to air toxics in the perinatal period</title><author>Heck, Julia E ; Park, Andrew S ; Qiu, Jiaheng ; Cockburn, Myles ; Ritz, Beate</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-60d48e7da12beb73e34743522b739b321f30e638473456ae35a7634998e610f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>1,3-Butadiene</topic><topic>692/499</topic><topic>692/699/67/1484</topic><topic>704/172</topic><topic>Acetaldehyde</topic><topic>Adult</topic><topic>Air Pollutants - adverse effects</topic><topic>Air pollution</topic><topic>Analysis</topic><topic>Benzene</topic><topic>Birth</topic><topic>Butadiene</topic><topic>California - epidemiology</topic><topic>Cancer</topic><topic>Cancer in children</topic><topic>Carcinogens</topic><topic>Carcinogens, Environmental - adverse effects</topic><topic>Carcinogens, Environmental - analysis</topic><topic>Case-Control 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Delayed Effects - chemically induced</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Registries</topic><topic>Regression analysis</topic><topic>Retina</topic><topic>Retinoblastoma</topic><topic>Retinoblastoma - chemically induced</topic><topic>Retinoblastoma - epidemiology</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Toluene</topic><topic>Tumors</topic><topic>Xylene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heck, Julia E</creatorcontrib><creatorcontrib>Park, Andrew S</creatorcontrib><creatorcontrib>Qiu, Jiaheng</creatorcontrib><creatorcontrib>Cockburn, Myles</creatorcontrib><creatorcontrib>Ritz, Beate</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central 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Abstracts</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of exposure science & environmental epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heck, Julia E</au><au>Park, Andrew S</au><au>Qiu, Jiaheng</au><au>Cockburn, Myles</au><au>Ritz, Beate</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoblastoma and ambient exposure to air toxics in the perinatal period</atitle><jtitle>Journal of exposure science & environmental epidemiology</jtitle><stitle>J Expo Sci Environ Epidemiol</stitle><addtitle>J Expo Sci Environ Epidemiol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>25</volume><issue>2</issue><spage>182</spage><epage>186</epage><pages>182-186</pages><issn>1559-0631</issn><eissn>1559-064X</eissn><abstract>We examined ambient exposure to specific air toxics in the perinatal period in relation to retinoblastoma development. Cases were ascertained from California Cancer Registry records of children diagnosed between 1990 and 2007 and matched to California birth certificates. Controls were randomly selected from state birth records for the same time period. We chose 27 air toxics for the present study that had been listed as possible, probable, or established human carcinogens by the International Agency for Research on Cancer. Children (103 cases and 30,601 controls) included in the study lived within 5 miles of an air pollution monitor. Using logistic regression analyses, we modeled the risk of retinoblastoma due to air toxic exposure, separately for exposures in pregnancy and the first year of life. With a per interquartile range increase in air toxic exposure, retinoblastoma risk was found to be increased with pregnancy exposure to benzene (OR=1.67, 95% CI: 1.06, 2.64) and other toxics which primarily arise from gasoline and diesel combustion: toluene, 1,3-butadiene, ethyl benzene, ortho-xylene, and meta/para-xylene; these six toxics were highly correlated. Retinoblastoma risk was also increased with pregnancy exposure to chloroform (OR=1.35, 95% CI: 1.07, 1.70), chromium (OR=1.29, 95% CI: 1.04, 1.60), para-dichlorobenzene (OR=1.24, 95% CI: 1.04, 1.49), nickel (OR=1.48, 95% CI: 1.08, 2.01), and in the first year of life, acetaldehyde (OR=1.62, 95% CI: 1.06, 2.48). Sources of these agents are discussed.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>24280682</pmid><doi>10.1038/jes.2013.84</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1,3-Butadiene 692/499 692/699/67/1484 704/172 Acetaldehyde Adult Air Pollutants - adverse effects Air pollution Analysis Benzene Birth Butadiene California - epidemiology Cancer Cancer in children Carcinogens Carcinogens, Environmental - adverse effects Carcinogens, Environmental - analysis Case-Control Studies Chemical industry Child, Preschool Children Chloroform Chromium Dichlorobenzene Environmental aspects Environmental Monitoring Epidemiology Ethyl benzene Exposure Female Gasoline Gasoline - adverse effects Gasoline - analysis Health aspects Health risk assessment Humans Hydrocarbons Infant Logistic Models Male Maternal Exposure - adverse effects Medicine Medicine & Public Health Nickel original-article p-Xylene Pediatric research Perinatal Care Perinatal exposure Pollution monitoring Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - epidemiology Registries Regression analysis Retina Retinoblastoma Retinoblastoma - chemically induced Retinoblastoma - epidemiology Risk Risk factors Toluene Tumors Xylene |
| title | Retinoblastoma and ambient exposure to air toxics in the perinatal period |
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