Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction

Xerostomia as a result of salivary gland damage is a permanent and debilitating side effect of radiotherapy for head and neck cancers. Effective treatments for protecting, or restoring, salivary gland function are not available. Here we report that irradiation treatment leads to activation of the ca...

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Veröffentlicht in:	Nature communications 2013, Vol.4 (1), p.1515-1515, Article 1515
Hauptverfasser:	Liu, Xibao, Cotrim, Ana, Teos, Leyla, Zheng, Changyu, Swaim, William, Mitchell, James, Mori, Yasuo, Ambudkar, Indu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/485 692/308 692/700/565/2194 Acinar Cells - drug effects Acinar Cells - metabolism Acinar Cells - pathology Acinar Cells - radiation effects Animals Benzamides - pharmacology Calcium - metabolism Cancer therapies Carbachol - pharmacology Cell Line Cell Survival - drug effects Cell Survival - radiation effects Enzyme Inhibitors - pharmacology Exocrine glands Free radicals Head & neck cancer Humanities and Social Sciences Humans Hydrogen Peroxide - pharmacology Ion Channel Gating - drug effects Ion Channel Gating - radiation effects Mice Mice, Inbred C57BL multidisciplinary Physiology Piperidines - pharmacology Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Radiation Injuries - pathology Radiation Injuries - physiopathology Radiation Injuries - prevention & control Radiation therapy Saliva - drug effects Saliva - radiation effects Saliva - secretion Salivary Glands - metabolism Salivary Glands - pathology Salivary Glands - physiopathology Salivary Glands - radiation effects Salivation - drug effects Salivation - radiation effects Science Science (multidisciplinary) Submandibular Gland - metabolism Submandibular Gland - pathology Submandibular Gland - physiopathology Submandibular Gland - radiation effects TRPM Cation Channels - deficiency TRPM Cation Channels - metabolism X-Rays
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