Challenges in the Pharmacogenomic Annotation of Whole Genomes

Next‐generation sequencing technologies have enabled the sequencing of an entire genome for less than $4,000. With access to all the genetic variation in an individual, our task will be to use this information to assess the genetic influences on drug efficacy, toxicity, and dosage. Clinical Pharmaco...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2013-08, Vol.94 (2), p.211-213
Hauptverfasser:	Altman, R B, Whirl-Carrillo, M, Klein, T E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Gene Frequency Genetic Variation Genome, Human Guidelines as Topic Humans Medical sciences Pharmacogenetics - organization & administration Pharmacogenetics - standards Pharmacology. Drug treatments Sequence Analysis, DNA
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Next‐generation sequencing technologies have enabled the sequencing of an entire genome for less than $4,000. With access to all the genetic variation in an individual, our task will be to use this information to assess the genetic influences on drug efficacy, toxicity, and dosage. Clinical Pharmacology & Therapeutics (2013); 94 2, 211–213. doi:10.1038/clpt.2013.111
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2013.111