Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model
Fermented dairy products are the usual carriers for the delivery of probiotics to humans, Bifidobacterium and Lactobacillus being the most frequently used bacteria. In this work, the strains Bifidobacterium animalis subsp. lactis IPLA R1 and Bifidobacterium longum IPLA E44 were tested for their capa...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-9 |
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| creator | González, Celestino de los Reyes-Gavilán, Clara G. Ruas-Madiedo, Patricia Salazar, Nuria Suárez, Ana Gueimonde, Miguel Cabello, Estefanía López, Patricia Garrido, Pablo Moran, Javier |
| description | Fermented dairy products are the usual carriers for the delivery of probiotics to humans, Bifidobacterium and Lactobacillus being the most frequently used bacteria. In this work, the strains Bifidobacterium animalis subsp. lactis IPLA R1 and Bifidobacterium longum IPLA E44 were tested for their capability to modulate immune response and the insulin-dependent glucose homeostasis using male Wistar rats fed with a standard diet. Three intervention groups were fed daily for 24 days with 10% skimmed milk, or with 109 cfu of the corresponding strain suspended in the same vehicle. A significant increase of the suppressor-regulatory TGF-β cytokine occurred with both strains in comparison with a control (no intervention) group of rats; the highest levels were reached in rats fed IPLA R1. This strain presented an immune protective profile, as it was able to reduce the production of the proinflammatory IL-6. Moreover, phosphorylated Akt kinase decreased in gastroctemius muscle of rats fed the strain IPLA R1, without affecting the glucose, insulin, and HOMA index in blood, or levels of Glut-4 located in the membrane of muscle and adipose tissue cells. Therefore, the strain B. animalis subsp. lactis IPLA R1 is a probiotic candidate to be tested in mild grade inflammation animal models. |
| doi_str_mv | 10.1155/2014/106290 |
| format | Article |
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In this work, the strains Bifidobacterium animalis subsp. lactis IPLA R1 and Bifidobacterium longum IPLA E44 were tested for their capability to modulate immune response and the insulin-dependent glucose homeostasis using male Wistar rats fed with a standard diet. Three intervention groups were fed daily for 24 days with 10% skimmed milk, or with 109 cfu of the corresponding strain suspended in the same vehicle. A significant increase of the suppressor-regulatory TGF-β cytokine occurred with both strains in comparison with a control (no intervention) group of rats; the highest levels were reached in rats fed IPLA R1. This strain presented an immune protective profile, as it was able to reduce the production of the proinflammatory IL-6. Moreover, phosphorylated Akt kinase decreased in gastroctemius muscle of rats fed the strain IPLA R1, without affecting the glucose, insulin, and HOMA index in blood, or levels of Glut-4 located in the membrane of muscle and adipose tissue cells. Therefore, the strain B. animalis subsp. lactis IPLA R1 is a probiotic candidate to be tested in mild grade inflammation animal models.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/106290</identifier><identifier>PMID: 24971309</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Administration, Oral ; Animals ; Bifidobacterium ; Bifidobacterium - immunology ; Bifidobacterium - metabolism ; Bifidobacterium animalis ; Bifidobacterium longum ; Care and treatment ; Colleges & universities ; Cytokines ; Cytokines - metabolism ; Dairy products ; Fermentation ; Health aspects ; Homeostasis ; Humans ; Immunologic Factors - metabolism ; Inflammation ; Insulin ; Interleukin-6 - metabolism ; Lactobacillus ; Male ; Microorganisms ; Milk - microbiology ; Models, Animal ; Molecular weight ; Nutrition research ; Obesity ; Polysaccharides, Bacterial - metabolism ; Probiotics ; Probiotics - administration & dosage ; Rats ; Rats, Wistar ; Rodents</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-9</ispartof><rights>Copyright © 2014 Nuria Salazar et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Nuria Salazar et al. Nuria Salazar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Nuria Salazar et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-572b6da3b13425dc16ecbbe9ab794ccb9a35ca2c31eada431192c318ec5c5b233</citedby><cites>FETCH-LOGICAL-c490t-572b6da3b13425dc16ecbbe9ab794ccb9a35ca2c31eada431192c318ec5c5b233</cites><orcidid>0000-0003-1435-7628 ; 0000-0002-0192-901X ; 0000-0001-6158-9320 ; 0000-0001-7062-1855</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058098/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058098/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24971309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hudson, John Andrew</contributor><creatorcontrib>González, Celestino</creatorcontrib><creatorcontrib>de los Reyes-Gavilán, Clara G.</creatorcontrib><creatorcontrib>Ruas-Madiedo, Patricia</creatorcontrib><creatorcontrib>Salazar, Nuria</creatorcontrib><creatorcontrib>Suárez, Ana</creatorcontrib><creatorcontrib>Gueimonde, Miguel</creatorcontrib><creatorcontrib>Cabello, Estefanía</creatorcontrib><creatorcontrib>López, Patricia</creatorcontrib><creatorcontrib>Garrido, Pablo</creatorcontrib><creatorcontrib>Moran, Javier</creatorcontrib><title>Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Fermented dairy products are the usual carriers for the delivery of probiotics to humans, Bifidobacterium and Lactobacillus being the most frequently used bacteria. In this work, the strains Bifidobacterium animalis subsp. lactis IPLA R1 and Bifidobacterium longum IPLA E44 were tested for their capability to modulate immune response and the insulin-dependent glucose homeostasis using male Wistar rats fed with a standard diet. Three intervention groups were fed daily for 24 days with 10% skimmed milk, or with 109 cfu of the corresponding strain suspended in the same vehicle. A significant increase of the suppressor-regulatory TGF-β cytokine occurred with both strains in comparison with a control (no intervention) group of rats; the highest levels were reached in rats fed IPLA R1. This strain presented an immune protective profile, as it was able to reduce the production of the proinflammatory IL-6. Moreover, phosphorylated Akt kinase decreased in gastroctemius muscle of rats fed the strain IPLA R1, without affecting the glucose, insulin, and HOMA index in blood, or levels of Glut-4 located in the membrane of muscle and adipose tissue cells. Therefore, the strain B. animalis subsp. lactis IPLA R1 is a probiotic candidate to be tested in mild grade inflammation animal models.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Bifidobacterium</subject><subject>Bifidobacterium - immunology</subject><subject>Bifidobacterium - metabolism</subject><subject>Bifidobacterium animalis</subject><subject>Bifidobacterium longum</subject><subject>Care and treatment</subject><subject>Colleges & universities</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Dairy products</subject><subject>Fermentation</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immunologic Factors - metabolism</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Interleukin-6 - metabolism</subject><subject>Lactobacillus</subject><subject>Male</subject><subject>Microorganisms</subject><subject>Milk - microbiology</subject><subject>Models, Animal</subject><subject>Molecular weight</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Polysaccharides, Bacterial - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González, Celestino</au><au>de los Reyes-Gavilán, Clara G.</au><au>Ruas-Madiedo, Patricia</au><au>Salazar, Nuria</au><au>Suárez, Ana</au><au>Gueimonde, Miguel</au><au>Cabello, Estefanía</au><au>López, Patricia</au><au>Garrido, Pablo</au><au>Moran, Javier</au><au>Hudson, John Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Fermented dairy products are the usual carriers for the delivery of probiotics to humans, Bifidobacterium and Lactobacillus being the most frequently used bacteria. In this work, the strains Bifidobacterium animalis subsp. lactis IPLA R1 and Bifidobacterium longum IPLA E44 were tested for their capability to modulate immune response and the insulin-dependent glucose homeostasis using male Wistar rats fed with a standard diet. Three intervention groups were fed daily for 24 days with 10% skimmed milk, or with 109 cfu of the corresponding strain suspended in the same vehicle. A significant increase of the suppressor-regulatory TGF-β cytokine occurred with both strains in comparison with a control (no intervention) group of rats; the highest levels were reached in rats fed IPLA R1. This strain presented an immune protective profile, as it was able to reduce the production of the proinflammatory IL-6. Moreover, phosphorylated Akt kinase decreased in gastroctemius muscle of rats fed the strain IPLA R1, without affecting the glucose, insulin, and HOMA index in blood, or levels of Glut-4 located in the membrane of muscle and adipose tissue cells. Therefore, the strain B. animalis subsp. lactis IPLA R1 is a probiotic candidate to be tested in mild grade inflammation animal models.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24971309</pmid><doi>10.1155/2014/106290</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1435-7628</orcidid><orcidid>https://orcid.org/0000-0002-0192-901X</orcidid><orcidid>https://orcid.org/0000-0001-6158-9320</orcidid><orcidid>https://orcid.org/0000-0001-7062-1855</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Administration, Oral Animals Bifidobacterium Bifidobacterium - immunology Bifidobacterium - metabolism Bifidobacterium animalis Bifidobacterium longum Care and treatment Colleges & universities Cytokines Cytokines - metabolism Dairy products Fermentation Health aspects Homeostasis Humans Immunologic Factors - metabolism Inflammation Insulin Interleukin-6 - metabolism Lactobacillus Male Microorganisms Milk - microbiology Models, Animal Molecular weight Nutrition research Obesity Polysaccharides, Bacterial - metabolism Probiotics Probiotics - administration & dosage Rats Rats, Wistar Rodents |
| title | Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model |
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