A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation

Neuroblastoma, the most common extracranial solid tumor of childhood, arises from neural crest cell precursors that fail to differentiate. Inducing cell differentiation is an important therapeutic strategy for neuroblastoma. We developed a direct functional high-content screen to identify differenti...

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Veröffentlicht in:	Oncotarget 2014-05, Vol.5 (9), p.2499-2512
Hauptverfasser:	Zhao, Zhenze, Ma, Xiuye, Hsiao, Tzu-Hung, Lin, Gregory, Kosti, Adam, Yu, Xiaojie, Suresh, Uthra, Chen, Yidong, Tomlinson, Gail E, Pertsemlidis, Alexander, Du, Liqin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Blotting, Western Cell Differentiation Cell Proliferation Cyclin-Dependent Kinase 4 - genetics Cyclin-Dependent Kinase 4 - metabolism High-Throughput Screening Assays Humans Luciferases - metabolism MicroRNAs - genetics Neurites - metabolism Neurites - pathology Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Neurogenesis - genetics Real-Time Polymerase Chain Reaction Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tumor Cells, Cultured
Online-Zugang:	Volltext
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