The effect of acute kidney injury on long-term health-related quality of life: a prospective follow-up study
Acute kidney injury (AKI) is a serious complication in critically ill patients admitted to the Intensive Care Unit (ICU). We hypothesized that ICU survivors with AKI would have a worse health-related quality of life (HRQOL) outcome than ICU survivors without AKI. We performed a long-term prospective...
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| Veröffentlicht in: | Critical care (London, England) England), 2013-01, Vol.17 (1), p.R17-R17, Article R17 |
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| creator | Hofhuis, José G M van Stel, Henk F Schrijvers, Augustinus J P Rommes, Johannes H Spronk, Peter E |
| description | Acute kidney injury (AKI) is a serious complication in critically ill patients admitted to the Intensive Care Unit (ICU). We hypothesized that ICU survivors with AKI would have a worse health-related quality of life (HRQOL) outcome than ICU survivors without AKI.
We performed a long-term prospective observational study. Patients admitted for > 48 hours in a medical-surgical ICU were included and divided in two groups: patients who fulfilled RIFLE criteria for AKI and patients without AKI. We used the Short-Form 36 to evaluate HRQOL before admission (by proxy within 48 hours after admission of the patient), at ICU discharge, hospital discharge, 3 and 6 months following ICU discharge (all by patients). Recovery in HRQOL from ICU-admission onwards was assessed using linear mixed modelling.
Between September 2000 and January 2007 all admissions were screened for study participation. We included a total of 749 patients. At six months after ICU discharge 73 patients with AKI and 325 patients without AKI could be evaluated. In survivors with and without AKI, the pre-admission HRQOL (by proxy) and at six months after ICU discharge was significantly lower compared with an age matched general population. Most SF-36 dimensions changed significantly over time from ICU discharge. Change over time of HRQOL between the different AKI Rifle classes (Risk, Injury, Failure) showed no significant differences. At ICU discharge, scores were lowest in the group with AKI compared with the group without AKI for the physical functioning, role-physical and general health dimensions. However, there were almost no differences in HRQOL between both groups at six months.
The pre-admission HRQOL (by proxy) of AKI survivors was significantly lower in two dimensions compared with the age matched general population. Six months after ICU discharge survivors with and without AKI showed an almost similar HRQOL. However, compared with the general population with a similar age, HRQOL was poorer in both groups. |
| doi_str_mv | 10.1186/cc12491 |
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We performed a long-term prospective observational study. Patients admitted for > 48 hours in a medical-surgical ICU were included and divided in two groups: patients who fulfilled RIFLE criteria for AKI and patients without AKI. We used the Short-Form 36 to evaluate HRQOL before admission (by proxy within 48 hours after admission of the patient), at ICU discharge, hospital discharge, 3 and 6 months following ICU discharge (all by patients). Recovery in HRQOL from ICU-admission onwards was assessed using linear mixed modelling.
Between September 2000 and January 2007 all admissions were screened for study participation. We included a total of 749 patients. At six months after ICU discharge 73 patients with AKI and 325 patients without AKI could be evaluated. In survivors with and without AKI, the pre-admission HRQOL (by proxy) and at six months after ICU discharge was significantly lower compared with an age matched general population. Most SF-36 dimensions changed significantly over time from ICU discharge. Change over time of HRQOL between the different AKI Rifle classes (Risk, Injury, Failure) showed no significant differences. At ICU discharge, scores were lowest in the group with AKI compared with the group without AKI for the physical functioning, role-physical and general health dimensions. However, there were almost no differences in HRQOL between both groups at six months.
The pre-admission HRQOL (by proxy) of AKI survivors was significantly lower in two dimensions compared with the age matched general population. Six months after ICU discharge survivors with and without AKI showed an almost similar HRQOL. However, compared with the general population with a similar age, HRQOL was poorer in both groups.</description><identifier>ISSN: 1364-8535</identifier><identifier>EISSN: 1466-609X</identifier><identifier>EISSN: 1364-8535</identifier><identifier>DOI: 10.1186/cc12491</identifier><identifier>PMID: 23356544</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acute Kidney Injury - diagnosis ; Acute Kidney Injury - mortality ; Acute Kidney Injury - psychology ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Health Status ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quality of Life - psychology ; Survival Rate - trends ; Time Factors</subject><ispartof>Critical care (London, England), 2013-01, Vol.17 (1), p.R17-R17, Article R17</ispartof><rights>Copyright © 2013 Hofhuis et al.; licensee BioMed Central Ltd. 2013 Hofhuis et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b420t-2f266400d6e6688ed8055bd9c5640df0d77d9cce9236d2f115d0112c8171e913</citedby><cites>FETCH-LOGICAL-b420t-2f266400d6e6688ed8055bd9c5640df0d77d9cce9236d2f115d0112c8171e913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057105/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057105/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23356544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hofhuis, José G M</creatorcontrib><creatorcontrib>van Stel, Henk F</creatorcontrib><creatorcontrib>Schrijvers, Augustinus J P</creatorcontrib><creatorcontrib>Rommes, Johannes H</creatorcontrib><creatorcontrib>Spronk, Peter E</creatorcontrib><title>The effect of acute kidney injury on long-term health-related quality of life: a prospective follow-up study</title><title>Critical care (London, England)</title><addtitle>Crit Care</addtitle><description>Acute kidney injury (AKI) is a serious complication in critically ill patients admitted to the Intensive Care Unit (ICU). We hypothesized that ICU survivors with AKI would have a worse health-related quality of life (HRQOL) outcome than ICU survivors without AKI.
We performed a long-term prospective observational study. Patients admitted for > 48 hours in a medical-surgical ICU were included and divided in two groups: patients who fulfilled RIFLE criteria for AKI and patients without AKI. We used the Short-Form 36 to evaluate HRQOL before admission (by proxy within 48 hours after admission of the patient), at ICU discharge, hospital discharge, 3 and 6 months following ICU discharge (all by patients). Recovery in HRQOL from ICU-admission onwards was assessed using linear mixed modelling.
Between September 2000 and January 2007 all admissions were screened for study participation. We included a total of 749 patients. At six months after ICU discharge 73 patients with AKI and 325 patients without AKI could be evaluated. In survivors with and without AKI, the pre-admission HRQOL (by proxy) and at six months after ICU discharge was significantly lower compared with an age matched general population. Most SF-36 dimensions changed significantly over time from ICU discharge. Change over time of HRQOL between the different AKI Rifle classes (Risk, Injury, Failure) showed no significant differences. At ICU discharge, scores were lowest in the group with AKI compared with the group without AKI for the physical functioning, role-physical and general health dimensions. However, there were almost no differences in HRQOL between both groups at six months.
The pre-admission HRQOL (by proxy) of AKI survivors was significantly lower in two dimensions compared with the age matched general population. Six months after ICU discharge survivors with and without AKI showed an almost similar HRQOL. However, compared with the general population with a similar age, HRQOL was poorer in both groups.</description><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - mortality</subject><subject>Acute Kidney Injury - psychology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health Status</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Quality of Life - psychology</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><issn>1364-8535</issn><issn>1466-609X</issn><issn>1364-8535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v3CAQxa2qVZMmVb9Bxa29uGGMwXYOlaKofyJF6mUPuSEWhiwpNg7gVP72JdptlBx6Ambe_J6GV1UfgH4B6MWZ1tC0A7yqjqEVohZ0uHld7ky0dc8ZP6repXRHKXS9YG-ro4YxLnjbHld-s0OC1qLOJFii9JKR_HZmwpW46W6JKwkT8WG6rTPGkexQ-byrI3qV0ZD7RXmX18dR7yyeE0XmGNJccO4BiQ3ehz_1MpOUF7OeVm-s8gnfH86TavP92-byZ33968fV5cV1vW0bmuvGNkK0lBqBQvQ9mp5yvjWD5qVqLDVdVx4ah4YJ01gAbihAo3voAAdgJ9XXPXZetiMajVOOyss5ulHFVQbl5MvO5HbyNjzIlvIOKC-A8z1g68J_AC87OozyEEEZ_nxwj-F-wZTl6JJG79WEYUkSOIeSj2BDkX7aS3X5sxTRPlkAlY-5PoN-fL7Sk-5fkOwvi3igmA</recordid><startdate>20130128</startdate><enddate>20130128</enddate><creator>Hofhuis, José G M</creator><creator>van Stel, Henk F</creator><creator>Schrijvers, Augustinus J P</creator><creator>Rommes, Johannes H</creator><creator>Spronk, Peter E</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130128</creationdate><title>The effect of acute kidney injury on long-term health-related quality of life: a prospective follow-up study</title><author>Hofhuis, José G M ; van Stel, Henk F ; Schrijvers, Augustinus J P ; Rommes, Johannes H ; Spronk, Peter E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b420t-2f266400d6e6688ed8055bd9c5640df0d77d9cce9236d2f115d0112c8171e913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - mortality</topic><topic>Acute Kidney Injury - psychology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health Status</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Quality of Life - psychology</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hofhuis, José G M</creatorcontrib><creatorcontrib>van Stel, Henk F</creatorcontrib><creatorcontrib>Schrijvers, Augustinus J P</creatorcontrib><creatorcontrib>Rommes, Johannes H</creatorcontrib><creatorcontrib>Spronk, Peter E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Critical care (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hofhuis, José G M</au><au>van Stel, Henk F</au><au>Schrijvers, Augustinus J P</au><au>Rommes, Johannes H</au><au>Spronk, Peter E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of acute kidney injury on long-term health-related quality of life: a prospective follow-up study</atitle><jtitle>Critical care (London, England)</jtitle><addtitle>Crit Care</addtitle><date>2013-01-28</date><risdate>2013</risdate><volume>17</volume><issue>1</issue><spage>R17</spage><epage>R17</epage><pages>R17-R17</pages><artnum>R17</artnum><issn>1364-8535</issn><eissn>1466-609X</eissn><eissn>1364-8535</eissn><abstract>Acute kidney injury (AKI) is a serious complication in critically ill patients admitted to the Intensive Care Unit (ICU). We hypothesized that ICU survivors with AKI would have a worse health-related quality of life (HRQOL) outcome than ICU survivors without AKI.
We performed a long-term prospective observational study. Patients admitted for > 48 hours in a medical-surgical ICU were included and divided in two groups: patients who fulfilled RIFLE criteria for AKI and patients without AKI. We used the Short-Form 36 to evaluate HRQOL before admission (by proxy within 48 hours after admission of the patient), at ICU discharge, hospital discharge, 3 and 6 months following ICU discharge (all by patients). Recovery in HRQOL from ICU-admission onwards was assessed using linear mixed modelling.
Between September 2000 and January 2007 all admissions were screened for study participation. We included a total of 749 patients. At six months after ICU discharge 73 patients with AKI and 325 patients without AKI could be evaluated. In survivors with and without AKI, the pre-admission HRQOL (by proxy) and at six months after ICU discharge was significantly lower compared with an age matched general population. Most SF-36 dimensions changed significantly over time from ICU discharge. Change over time of HRQOL between the different AKI Rifle classes (Risk, Injury, Failure) showed no significant differences. At ICU discharge, scores were lowest in the group with AKI compared with the group without AKI for the physical functioning, role-physical and general health dimensions. However, there were almost no differences in HRQOL between both groups at six months.
The pre-admission HRQOL (by proxy) of AKI survivors was significantly lower in two dimensions compared with the age matched general population. Six months after ICU discharge survivors with and without AKI showed an almost similar HRQOL. However, compared with the general population with a similar age, HRQOL was poorer in both groups.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23356544</pmid><doi>10.1186/cc12491</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - diagnosis Acute Kidney Injury - mortality Acute Kidney Injury - psychology Aged Aged, 80 and over Female Follow-Up Studies Health Status Humans Male Middle Aged Prospective Studies Quality of Life - psychology Survival Rate - trends Time Factors |
| title | The effect of acute kidney injury on long-term health-related quality of life: a prospective follow-up study |
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