Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response

Trovafloxacin (TVX) is a drug that has caused idiosyncratic, drug-induced liver injury (IDILI) in humans. In a murine model of IDILI, otherwise nontoxic doses of TVX and the inflammagen lipopolysaccharide (LPS) interacted to produce pronounced hepatocellular injury. The liver injury depended on a TV...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-07, Vol.350 (1), p.164-170
Hauptverfasser:	Poulsen, Kyle L, Olivero-Verbel, Jesus, Beggs, Kevin M, Ganey, Patricia E, Roth, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism Cells, Cultured DNA Damage - drug effects DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Fluoroquinolones - antagonists & inhibitors Fluoroquinolones - toxicity Humans Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Morpholines - pharmacology Naphthyridines - antagonists & inhibitors Naphthyridines - toxicity Nitroso Compounds - pharmacology Pyrimidines - pharmacology Pyrones - pharmacology Signal Transduction - drug effects Toxicology Tumor Necrosis Factor-alpha - biosynthesis
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