Potent inhibition of alcohol self-administration in alcohol-preferring rats by a κ-opioid receptor antagonist

A substituted aryl amide derivative of 6-naltrexamine--17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-trimethylfluoro)benzamido]morphinan-hydrochloride--(compound 5), previously shown to be a potent κ-opioid receptor antagonist, was used to characterize the physicochemical properties a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-07, Vol.350 (1), p.171-180
Hauptverfasser:	Cashman, John R, Azar, Marc R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Alanine Transaminase - drug effects Animals Aspartate Aminotransferases - blood Aspartate Aminotransferases - drug effects Behavioral Pharmacology Chemical and Drug Induced Liver Injury - blood Conditioning, Operant - drug effects Ethanol - administration & dosage Male Morphinans - adverse effects Morphinans - pharmacokinetics Morphinans - pharmacology Naltrexone - adverse effects Naltrexone - analogs & derivatives Narcotic Antagonists - adverse effects Narcotic Antagonists - pharmacokinetics Narcotic Antagonists - pharmacology Rats Rats, Inbred Strains Self Administration Thioamides - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!