Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development

Influenza virus surface glycoprotein hemagglutinin (HA) is an excellent and chief target that elicits neutralizing antibodies during vaccination or natural infection. Its HA2 subunit (stem domain) is most conserved as compared to HA1 subunit (globular head domain). Current influenza vaccine relies o...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-7
Hauptverfasser:	Khanna, Madhu, Sharma, Sachin, Kumar, Binod, Rajput, Roopali
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglutination Animals Antibodies Bacterial infections Conserved Sequence Deoxyribonucleic acid DNA Genomes Health aspects Hemagglutinins - chemistry Hemagglutinins - immunology Humans Immunity Infections Influenza Influenza vaccines Influenza Vaccines - immunology Influenza virus Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology Pandemics Pharmaceutical research Product development Protein Structure, Tertiary Review Vaccines Vaccines, DNA - immunology Viral antibodies Viruses
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