The combination of rapamycin and MAPK inhibitors enhances the growth inhibitory effect on Nara-H cells

The inhibition of the mammalian target of rapamycin (mTOR) signaling pathway promotes the initiation of autophagy, and the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) is well known to induce autophagy. Autophagy is a self-defense mechanism of cancer ce...

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Veröffentlicht in:	International journal of molecular medicine 2014-06, Vol.33 (6), p.1491-1497
Hauptverfasser:	NAKAMURA, OSAMU, HITORA, TOSHIAKI, YAMAGAMI, YOSHIKI, MORI, MASAKI, NISHIMURA, HIDEKI, HORIE, RYOSUKE, YAMAGUCHI, KONOSUKE, YAMAMOTO, TETSUJI
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Apoptosis - drug effects Apoptosis - genetics Autophagy Blotting, Western Butadienes - pharmacology Cancer Cancer therapies Care and treatment Cell culture Cell cycle Cell growth Cell Line Cell Proliferation - drug effects Defense mechanisms Dosage and administration Experiments Gene expression Humans Kinases mammalian target of rapamycin MAP Kinase Signaling System - drug effects Microscopy Microscopy, Fluorescence mitogen-activated protein kinase Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Nitriles - pharmacology Phosphorylation Protein Kinase Inhibitors - pharmacology Proteins Rapamycin Reverse Transcriptase Polymerase Chain Reaction RNA Interference Self defense Signal Transduction - drug effects Sirolimus - pharmacology Studies
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