Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation

Asbestos exposure is related to various diseases including asbestosis and malignant mesothelioma (MM). Among the pathogenic mechanisms proposed by which asbestos can cause diseases involving epithelial and mesothelial cells, the most widely accepted one is the generation of reactive oxygen species a...

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Veröffentlicht in:	Particle and fibre toxicology 2014-05, Vol.11 (1), p.24-24, Article 24
Hauptverfasser:	Thompson, Joyce K, Westbom, Catherine M, MacPherson, Maximilian B, Mossman, Brooke T, Heintz, Nicholas H, Spiess, Page, Shukla, Arti
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Acids Analysis Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Asbestos Asbestos, Crocidolite - toxicity Blotting, Western Caspase 1 - metabolism Cell Line, Tumor Chemical bonds Dehydroascorbic Acid - metabolism Dinitrochlorobenzene - toxicity Enzyme Activation - drug effects Epithelium - drug effects Epithelium - pathology Experiments Fibers Gene Knockdown Techniques Humans Inflammation - pathology L-Lactate Dehydrogenase - metabolism Mesothelioma Oxidation Physiological aspects Proteins Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Respiratory tract diseases RNA, Small Interfering Studies Thioredoxin Reductase 1 - metabolism Thioredoxins - drug effects Thioredoxins - genetics
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