Aging of blood can be tracked by DNA methylation changes at just three CpG sites

BACKGROUND: Human aging is associated with DNA methylation changes at specific sites in the genome. These epigenetic modifications may be used to track donor age for forensic analysis or to estimate biological age. RESULTS: We perform a comprehensive analysis of methylation profiles to narrow down 1...

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Veröffentlicht in:	Genome Biology (Online Edition) 2014-02, Vol.15 (2), p.R24-R24, Article R24
Hauptverfasser:	Weidner, Carola Ingrid, Lin, Qiong, Koch, Carmen Maike, Eisele, Lewin, Beier, Fabian, Ziegler, Patrick, Bauerschlag, Dirk Olaf, Jöckel, Karl-Heinz, Erbel, Raimund, Mühleisen, Thomas Walter, Zenke, Martin, Brümmendorf, Tim Henrik, Wagner, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Amidohydrolases - genetics Analysis anemia Aplastic anemia biomarkers blood Blood Cells bone marrow Cellular Senescence - genetics CpG Islands - genetics Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics DNA methylation DNA Methylation - genetics Epigenesis, Genetic Epigenetic inheritance epigenetics genes Genetic aspects Genome, Human Humans Induced Pluripotent Stem Cells Integrin alpha2 - genetics lifestyle Methylation patients Physiological aspects sequence analysis Stem cells Telomeres
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