Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2

The p53 transcription factor is located at the core of a complex wiring of signaling pathways that are critical for the preservation of cellular homeostasis. Only recently it has become clear that p53 regulates the expression of several long intergenic noncoding RNAs (lincRNAs). However, relatively...

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Veröffentlicht in:	Genome biology 2013-01, Vol.14 (9), p.R104-R104
Hauptverfasser:	Marín-Béjar, Oskar, Marchese, Francesco P, Athie, Alejandro, Sánchez, Yolanda, González, Jovanna, Segura, Victor, Huang, Lulu, Moreno, Isabel, Navarro, Alfons, Monzó, Mariano, García-Foncillas, Jesús, Rinn, John L, Guo, Shuling, Huarte, Maite
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Cell Survival colon Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Epigenesis, Genetic epigenetics gene expression genes Genetic regulation Genetic transcription Histones - genetics Histones - metabolism homeostasis Humans Mice mitogen-activated protein kinase Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism neoplasm cells neoplasms NIH 3T3 Cells non-coding RNA Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Regulació genètica RNA RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism signal transduction Transcripció genètica transcription factors transforming growth factor beta Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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