Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2

Estrogen signaling is pivotal in the progression of estrogen receptor positive breast cancer primarily by the regulation of cell survival and proliferation. Micro (mi)RNAs have been demonstrated to be regulated by estrogen to mediate estrogenic effects. Herein, we determined the role of estrogen reg...

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Veröffentlicht in:	Breast cancer research : BCR 2014-04, Vol.16 (2), p.R40-R40, Article R40
Hauptverfasser:	Tan, Sheng, Ding, Keshuo, Li, Rui, Zhang, Weijie, Li, Gaopeng, Kong, Xiangjun, Qian, Pengxu, Lobie, Peter E, Zhu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha Karyopherins - genetics alpha Karyopherins - metabolism Animals Blotting, Western Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor Cell Proliferation - drug effects DNA Helicases - genetics DNA Helicases - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Estradiol - pharmacology Estrogens - pharmacology Gene Expression Regulation, Neoplastic - drug effects Humans MCF-7 Cells Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Receptors, Estrogen - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Xenograft Model Antitumor Assays
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